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Stains
Actin, alpha smooth muscle type

Reviewer: Gina Johnson, M.D. (see Reviewers page)
Revised: 7 November 2014, last major update November 2013
Copyright: (c) 2002-2014, PathologyOutlines.com, Inc.

General
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Terminology
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Clinical features
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Interpretation
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Uses by Pathologists
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Micro images
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Normal: breast myoepithelial cell disruptions

Normal: breast myoepithelial cells

Normal: decidual stromal cells

Normal: eye choroid and sclera


Normal: liver (fetal)


Ameloblastic carcinoma

Bladder: PEComa

Bone: glomus tumor


Breast: myoepithelial cells (fig C/G)

Breast: adenoid cystic carcinoma (fig B) vs collagenous spherulosis (fig G)

Breast: basal-like carcinoma (fig a)

Breast: cellular fibroadenoma


Breast: leiomyoma

Breast: fibromatosis

Breast: hamartomas-myoid


Colon (left to right): carcinosarcoma; leiomyoma (top); Peutz Jeghers polyp (fig 4)

Colon and small intestine: normal and intestinal pseudoobstruction

Crohn disease: obliterative muscularization


Eye: MFH of conjunctiva (top left)

Heart: fetus with heart block

Heart scar tissue


Inflammatory myofibroblastic tumor (left to right): bone, gallbladder, salivary gland (fig 3b)

Kidney (left to right): atypical epithelioid angiomyolipoma (two images), focal segmental glomerulosclerosis


Leiomyosarcoma (left to right): bladder (fig C), cervix, esophagus

Liver: left-epithelioid angiomyolipoma; right-glomangioma (fig 5)


Lung: COPD

Lung: lymphangio-leiomyomatosis

Lung: adenocarcinoma, subepithelial myofibroblasts


Myofibroblastic sarcoma (left: smooth muscle actin, right: calponin)

Myofibroblastic sarcoma (left: smooth muscle actin, right MIB-1)

Neuroblastoma


Placenta accreta (fig 3)

Plexiform fibrohistiocytic tumor

Pleomorphic sarcoma / MFH


Salivary gland duct carcinoma

Salivary gland sialometaplasia in parotid node

Sinonasal hemangiopericytoma


Stomach: left-gastric carcinoma-diffuse type (fig A); right-gastric carcinoma-intestinal type (fig A)

Submandibular gland - adenoid cystic carcinoma

Positive stains: Normal
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Positive stains: Disease
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Negative stains: Normal
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Negative stains: Disease
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End of Stains > Actin, alpha smooth muscle type


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