Author: Gina Johnson, M.D.

Revised: 23 March 2017, last major update September 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: AMACR[title]
Page views in 2018: 15,768
Page views in 2019 to date: 936
Cite this page: Johnson, G. AMACR. website. Accessed January 19th, 2019.
Definition / general
  • Alpha Methyl Acyl Coenzyme A Racemase; also called P504S
  • Identified from prostate adenocarcinoma by cDNA library subtraction, coupled with high throughput microarray screening of human prostatic tissue
  • A mitochondrial and peroxisomal enzyme involved in beta-oxidation of dietary branched-chain fatty acids and fatty acid derivatives (including bile acid intermediates)
  • AMACR deficiency is rare cause of cerebellar ataxia (Neurology 2011;76:1768)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Colonic adenoma

Quality control for AMACR staining


High grade PIN


Positive stains
Negative stains