Topic Completed: 1 September 2013

Revised: 26 March 2020

Copyright: 2003-2020,, Inc.

PubMed Search: AMACR[title]

Gina Johnson, M.D.
Page views in 2019: 19,264
Page views in 2020 to date: 4,948
Cite this page: Johnson G. AMACR. website. Accessed March 29th, 2020.
Definition / general
  • Alpha Methyl Acyl Coenzyme A Racemase; also called P504S
  • Identified from prostate adenocarcinoma by cDNA library subtraction, coupled with high throughput microarray screening of human prostatic tissue
  • A mitochondrial and peroxisomal enzyme involved in beta-oxidation of dietary branched-chain fatty acids and fatty acid derivatives (including bile acid intermediates)
  • AMACR deficiency is rare cause of cerebellar ataxia (Neurology 2011;76:1768)
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Colonic adenoma

Quality control for AMACR staining


High grade PIN


Positive stains
Negative stains
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