Stains
AMACR

Author: Gina Johnson, M.D. (see Authors page)

Revised: 3 November 2015, last major update September 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: AMACR[title]
Definition / General
  • Alpha Methyl Acyl Coenzyme A Racemase; also called P504S
  • Identified from prostate adenocarcinoma by cDNA library subtraction, coupled with high throughput microarray screening of human prostatic tissue
  • A mitochondrial and peroxisomal enzyme involved in beta-oxidation of dietary branched-chain fatty acids and fatty acid derivatives (including bile acid intermediates)
  • AMACR deficiency is rare cause of cerebellar ataxia (Neurology 2011;76:1768)
Uses by Pathologists
Micro Images

Images hosted on other servers:

Colonic adenoma

Quality control for AMACR staining


Prostate-

Adenosis

High grade PIN

Suspicious for adenocarcinoma


Adenocarcinoma

Adenocarcinoma

Adenocarcinoma


Positive Stains
Negative Stains