Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 18 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: AML1[title]
- Gene at 21q22 is DNA binding component of AML1/CBF beta transcription factor complex, most frequent target of translocations in AML via t(8;21) [AML1-ETO]; t(12;21); t(3;21) [AML1-EVI1]
- Fusion products (below) suppress normal AML1 mediated transactivating activity
- Normal AML1 required to establish fetal liver-derived definitive hematopoiesis (stem cells to definitive hematopoietic elements)
End of Stains > AML1
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