Stains
AML1



Topic Completed: 1 June 2015

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: AML1[title]
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Table of Contents
Definition / general
Cite this page: Pernick N. AML1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsaml1.html. Accessed May 21st, 2019.
Definition / general
  • Gene at 21q22 is DNA binding component of AML1/CBF beta transcription factor complex, most frequent target of translocations in AML via t(8;21) [AML1-ETO]; t(12;21); t(3;21) [AML1-EVI1]
  • Fusion products (below) suppress normal AML1 mediated transactivating activity
  • Normal AML1 required to establish fetal liver-derived definitive hematopoiesis (stem cells to definitive hematopoietic elements)
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