Stains
AML1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 September 2015, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: AML1[title]
Table of Contents
General
General
  • Gene at 21q22 is DNA binding component of AML1/CBF beta transcription factor complex, most frequent target of translocations in AML via t(8;21) [AML1-ETO]; t(12;21); t(3;21) [AML1-EVI1]
  • Fusion products (below) suppress normal AML1 mediated transactivating activity
  • Normal AML1 required to establish fetal liver-derived definitive hematopoiesis (stem cells to definitive hematopoietic elements)