Author: Nat Pernick, M.D. (see Authors page)

Revised: 25 September 2015, last major update January 2014

Copyright: (c) 2003-2015,, Inc.

PubMed Search: stainsamy1a
Definition / General
  • Also known as amylase alpha 1A
  • Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, the first step in digestion of dietary starch and glycogen
  • Humans have cluster of several amylase genes expressed at high levels in salivary gland or pancreas (NCBI Gene)
Clinical Features
  • AMY1 genes show extensive copy number variation, which is directly proportional to salivary α-amylase content in saliva (J Nutrigenet Nutrigenomics 2012;5:117)
  • Gene is deleted in chromophobe renal cell carcinoma but not oncocytoma
Uses by Pathologists
  • Differentiate oncocytoma (AMY1A+) from chromophobe renal cell carcinoma (both classic and eosinophilic variants are negative, Am J Surg Pathol 2013;37:1824)
Positive Staining - Disease
  • Oncocytoma
Negative Staining
  • Renal carcinomas: chromophone, clear cell, papillary