Androgen receptor

Author: Gina Johnson, M.D. (see Authors page)

Revised: 7 March 2018, last major update January 2014

Copyright: (c) 2003-2018,, Inc.

PubMed Search: androgen receptor[title]
Cite this page: Androgen receptor. website. Accessed March 19th, 2018.
Definition / general
  • See also Androgen Receptor in Breast-malignant chapter
  • Androgen receptor (AR) is a member of the superfamily of ligand responsive transcription regulators
  • The androgen receptor functions in the nucleus where it is believed to act as a transcriptional regulator mediating the action of male sex hormones (androgens)
  • Nuclear stain
Uses by pathologists
  • Apocrine marker
  • Breast carcinoma marker helpful in determining primary site of metastases
  • Paget disease marker
  • Sebaceous carcinoma marker; may help differentiate from squamous cell and basal cell carcinomas (Am J Clin Pathol 2010;134:22)
Microscopic (histologic) images

Images hosted on Pathout server:

Salivary gland low grade cribriform cystadenocarcinoma - negative for AR

Images hosted on other servers:

Breast: apocrine DCIS

Breast: apocrine metaplasia

Prostate carcinoma
metastatic to bone

Spindle cell lipoma

Images hosted on

Breast: various carcinomas

Breast: Paget disease

Positive staining - normal
Positive staining - disease
Negative staining
Additional references