Stains - Androgen receptor

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Stains

Androgen receptor

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 18 November 2011, last major update November 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● Interpretation: nuclear stain

Uses for Pathologists
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● (1) Apocrine marker
● (2) Breast carcinoma marker helpful in determining primary site of metastases
● (3) Paget's disease marker
● (4) Sebaceous carcinoma marker; may help differentiate from squamous cell and basal cell carcinomas (Am J Clin Pathol 2010;134:22)

Micro images-Andorgen receptor staining
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Breast: apocrine DCIS

Breast: apocrine metaplasia

Breast: various molecular types of carcinoma

Paget's disease of vulva (fig 1c) and breast (fig 1d)

Prostate carcinoma metastatic to bone

Spindle cell lipoma

Salivary gland low grade cribriform cystadenocarcinoma is negative for androgen receptor

Positive staining - normal
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● Skin apocrine and sebaceous glands, prostate basal cells

Positive staining - disease
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● Breast: apocrine metaplasia, apocrine DCIS, apocrine carcinoma (54%), cystic hypersecretory DCIS (Histopathology 2005;46:43), high grade DCIS, high grade invasive breast carcinoma (primary and metastatic), mammary and extramammary Paget’s disease (Mod Pathol 2005;18:1283), PASH-spindle cells (Int J Clin Exp Pathol 2009;3:87), sebaceous carcinoma, tall cell-like tumors
● Nasal cavity: nasopharyngeal angiofibroma (75%, Mod Pathol 1998;11:1122)
● Ovary: serous tumors (50%), Sertoli-Leydig tumor
● Salivary glands: giant cell tumor, salivary duct carcinomas (Am J Clin Pathol 2003;119:801)
● Skin: Paget's disease, sebaceous carcinoma (variable)
● Soft tissue: desmoid tumor, spindle cell lipoma in men and usually women (Arch Pathol Lab Med 2008;132:81)
● Uterus: adenosarcoma, endometrial polyp with atypical features, endometrial stromal nodule, leiomyosarcoma (variable)

Negative staining
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● Adenomatoid tumor, BRCA1 breast carcinomas, breast fibromatosis (Arch Pathol Lab Med 2000;124:276), neuroendocrine cells

Additional references
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● Wikipedia

End of Stains > Androgen receptor

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