Androgen receptor

Author: Gina Johnson, M.D. (see Authors page)

Revised: 25 September 2015, last major update January 2014

Copyright: (c) 2003-2015,, Inc.

PubMed Search: androgen receptor[title]
  • Androgen receptor (AR) is a member of the superfamily of ligand responsive transcription regulators
  • The androgen receptor functions in the nucleus where it is believed to act as a transcriptional regulator mediating the action of male sex hormones (androgens)
  • Nuclear stain
Uses by Pathologists
  • Apocrine marker
  • Breast carcinoma marker helpful in determining primary site of metastases
  • Paget disease marker
  • Sebaceous carcinoma marker; may help differentiate from squamous cell and basal cell carcinomas (Am J Clin Pathol 2010;134:22)
Micro Images

Breast: apocrine DCIS

Breast: apocrine metaplasia

Breast: Paget disease

Breast: various carcinomas

Prostate carcinoma
metastatic to bone

Spindle cell lipoma

Salivary gland low grade cribriform
cystadenocarcinoma - negative for AR

Positive Staining - Normal
Positive Staining - Disease
Negative Staining
Additional References