Stains
Apolipoprotein D (apoD)



Topic Completed: 1 June 2005

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Apolipoprotein D[title]
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Table of Contents
Definition / general
Cite this page: Pernick N. Apolipoprotein D (apoD). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsapod.html. Accessed May 21st, 2019.
Definition / general
  • Member of lipocalin superfamily of proteins involved in transport of cholesterol, steroid hormones and other small hydrophobic molecules
  • Correlates with cell cycle inhibition in various situations including cellular senescence
  • High levels in fibrocystic breast disease and HDL, but produced by almost all tissues in body
  • Expression upregulated in nonneoplastic regenerating peripheral nerve compared to normal, then downregulated during transformation to MPNST (Hum Pathol 2005;36:987)
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