Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update February 2014

Copyright: (c) 2003-2015,, Inc.

PubMed Search: ATRX[title]
  • Alpha-Thalassemia/mental Retardation syndrome X-linked
  • Chromatin remodelling protein important in DNA replication, telomere stability, gene transcription, chromosome congression and cohesion during cell division (Epigenetics 2013;8:3)
  • Member of SWI/SNF protein family of DNA dependent ATPases
  • Is recruited to site of DNA damage; required for efficient checkpoint activation and faithful replication restart (J Biol Chem 2013;288:6342)
  • Death domain-associated protein (Daxx) cooperates with ATRX
Clinical Features
Uses by Pathologists
  • See clinical features above
Micro Images

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Pancreas: ALT+ tumors

Pancreas: MEN1 microadenoma and
pancreatic neuroendocrine tumor