Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 October 2015, last major update June 2005

Copyright: (c)2003-2015,, Inc.

PubMed Search: B72.3[title]
  • Definition: monoclonal antibody that recognizes tumor-associated glyocoprotein 72 (TAG-72), a mucin-like sugar and protein complex on the surface of many cancer cells
  • Antibody is directed against the Sialyl-Tn blood group antigen
  • Cytoplasmic staining
Uses by Pathologists
Positive Staining - Normal
Positive Staining - Malignant
  • Angiosarcoma-epithelioid, breast apocrine carcinoma (92%), breast ductal carcinoma, colonic adenocarcinoma, endometrial carcinoma, esophageal squamous cell carcinoma, lung adenocarcinoma, ovarian serous tumors and implants, pancreatic ductal adenocarcinoma and intraductal oncocytic papillary neoplasm, prostatic adenocarcinoma, salivary gland carcinoma including duct carcinoma, mucoepidermoid carcinoma (Laryngoscope 1994;104:304) and malignant mixed tumor; testicular ovarian surface epithelial-like tumor, testicular serous papillary carcinoma, vulvar Paget’s disease
Negative Stains

Normal tissue:
  • Mesothelial cells, most benign cells except colon, duodenum, endometrium, gastric

  • Adrenocortical adenoma, adrenocortical carcinoma, anaplastic meningioma, lung small cell carcinoma, mesothelial cell inclusions in lymph nodes, mesothelial cysts in the kidney, mesothelioma, ovarian adnexal tumor of probable wolffian origin, ovarian primary retroperitoneal mucinous cystadenoma, ovarian small cell carcinoma-hypercalcemic type
Micro Images

Bronchioalveolar carcinoma of lung: A-H&E, B-cytoplasmic staining for CEA, C-cytoplasmic staining for B72.3