Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update January 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: bcl6[title]
Definition / General
  • Transcription factor at 3q27 normally expressed in germinal centers and in 5-15% of intrafollicular CD4+ T cells
  • Protects germinal center (GC) B cells against DNA damage-induced apoptosis during somatic hypermutation and class-switch recombination (J Exp Med 2010;207:1209)
  • Translocations help define "double hit" lymphomas (Am J Clin Pathol 2010;134:258)
  • Nuclear staining
Uses by Pathologists
  • Germinal center marker (also CD10)
  • Marker for follicular lymphoma (30-80%) of cases, can distinguish from MALT (bcl6-)
  • Double staining of CD3 and bcl6 is helpful in appreciating follicular T-helper cell immunophenotype of angioimmunoblastic T-cell lymphoma (Hum Pathol 2010;41:79)
Micro Images

Images hosted on other servers:

Follicular lymphoma: left-spleen (fig C), right-site unspecified

Intestinal large B-cell lymphoma (fig 3)

Mantle cell lymphoma case is bcl6+ (uncommon)


Nodal marginal zone lymphoma (top)
is bcl6- versus bcl6+ diffuse follicular
center lymphoma (bottom)

Images hosted on

Diffuse blastoid B cell lymphoma (fig C)

Diffuse large B cell lymphoma-leg type (left) versus primary cutaneous follicular center lymphoma (right)

Diffuse large B cell lymphoma (fig E)

Positive Staining - Normal
Positive Staining - Disease
Negative Staining
Molecular / Cytogenetics Description
Molecular / Cytogenetics Images

Dual-color FISH analysis for BCL6