Stains
BCL6

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 October 2017, last major update January 2012

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: BCL6[title]
Cite this page: Pernick, N. BCL6. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbcl6.html. Accessed October 20th, 2017.
Definition / general
  • Transcription factor at 3q27 normally expressed in germinal centers and in 5 - 15% of intrafollicular CD4+ T cells
  • Protects germinal center (GC) B cells against DNA damage induced apoptosis during somatic hypermutation and class switch recombination (J Exp Med 2010;207:1209)
  • Translocations help define "double hit" lymphomas (Am J Clin Pathol 2010;134:258)
Interpretation
  • Nuclear staining
Uses by pathologists
  • Germinal center marker (also CD10)
  • Marker for follicular lymphoma (30 - 80%) of cases, can distinguish from MALT (BCL6-)
  • Double staining of CD3 and BCL6 is helpful in appreciating follicular T helper cell immunophenotype of angioimmunoblastic T cell lymphoma (Hum Pathol 2010;41:79)
Microscopic (histologic) images

Images hosted on other servers:

Follicular lymphoma: left - spleen (fig C)

Intestinal large B cell lymphoma (fig 3)

Mantle cell lymphoma case is BCL6+ (uncommon)

Neuroblastoma

     

Nodal marginal zone lymphoma (top) is
BCL6- versus BCL6+ diffuse follicular
center lymphoma (bottom)

Positive staining - normal
Positive staining - disease
Negative staining
Molecular / cytogenetics description