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Table of Contents
Definition / general | Diagrams / tables | Clinical features | Interpretation | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | VideosCite this page: bcl-XL. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbclxl.html. Accessed July 12th, 2017.
Definition / general
- Longer transcript of bcl-X
- Protects cells from apoptosis (i.e. anti-apoptotic marker)
- Relative amounts of pro- and anti-survival Bcl-2 family of proteins determine if cell will undergo cell death - if more Bcl-xL is present, pores are non-permeable and the cell survives (Wikipedia)
Diagrams / tables
Signal transduction pathways
Clinical features
- Upregulated during melanoma progression (Mod Pathol 2007;20:416)
Interpretation
- Cytoplasmic staining; colon carcinoma cells serve as positive control
Uses by pathologists
- Expression may be poor prognostic factor in squamous cell carcinoma in Egypt (BMC Cancer 2011 Jan 12;11:16)
Microscopic (histologic) images
Images hosted on Nature.com:
Diffuse large B cell lymphoma (fig F)
Ba: compound nevus is negative
Bb: melanoma >1.0 mm thick (times 400) is strongly positive
Bc: subcutaneous metastasis is positive
Positive staining - normal
- Classical Hodgkin lymphoma Reed-Sternberg cells (Hum Pathol 2007;38:103)
Videos
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