Stains - bcl-XL

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Stains

bcl-XL

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 30 January 2013, last major update January 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: bcl-Xl [title]
Broken links/comments: click here or email CopyrightPathOut@gmail.com, subject=Stainsbcl-Xl

Definition
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● Longer transcript of bcl-X
● Protects cells from apoptosis (i.e. anti-apoptotic marker)
● Relative amounts of pro- and anti-survival Bcl-2 family of proteins determine if cell will undergo cell death - if more Bcl-xL is present, pores are non-permeable and the cell survives (Wikipedia)

Diagrams
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Signal transduction pathways

Clinical features
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● Upregulated during melanoma progression (Mod Pathol 2007;20:416)

Interpretation
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● Cytoplasmic staining; colon carcinoma cells serve as positive control

Uses by pathologists
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● Expression may be poor prognostic factor in squamous cell carcinoma in Egypt (BMC Cancer 2011 Jan 12;11:16)

Micro images
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Ba: compound nevus is negative; Bb: melanoma >1.0 mm thick (times 400) is strongly positive; Bc: subcutaneous metastasis is positive

Diffuse large B cell lymphoma (fig f)

Positive staining - normal
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● Classical Hodgkin lymphoma Reed-Sternberg cells (Hum Pathol 2007;38:103)

Videos
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● Bcl-Xl forms pore

End of Stains > bcl-XL

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