Stains
Bcl-xL

Author: Nat Pernick, M.D.

Revised: 28 March 2018, last major update August 2015

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Bcl-xL[title]
Cite this page: Pernick, N. Bcl-xL. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbclxl.html. Accessed July 23rd, 2018.
Definition / general
  • Longer transcript of Bcl-x
  • Protects cells from apoptosis (i.e. anti-apoptotic marker)
  • Relative amounts of pro- and anti-survival BCL2 family of proteins determine if cell will undergo cell death - if more Bcl-xL is present, pores are non-permeable and the cell survives (Wikipedia)
Diagrams / tables

Signal transduction pathways

Clinical features
Interpretation
  • Cytoplasmic staining; colon carcinoma cells serve as positive control
Uses by pathologists
Positive staining - normal
Videos

Bcl-xL forms pore