Author: Nat Pernick, M.D.

Revised: 28 March 2018, last major update August 2015

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Bcl-xL[title]
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Cite this page: Pernick, N. Bcl-xL. website. Accessed January 22nd, 2019.
Definition / general
  • Longer transcript of Bcl-x
  • Protects cells from apoptosis (i.e. anti-apoptotic marker)
  • Relative amounts of pro- and anti-survival BCL2 family of proteins determine if cell will undergo cell death - if more Bcl-xL is present, pores are non-permeable and the cell survives (Wikipedia)
Diagrams / tables

Signal transduction pathways

Clinical features
  • Cytoplasmic staining; colon carcinoma cells serve as positive control
Uses by pathologists
Positive staining - normal

Bcl-xL forms pore