Stains
Bcl-xL

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 October 2017, last major update August 2015

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Bcl-xL[title]
Cite this page: Bcl-xL. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbclxl.html. Accessed October 22nd, 2017.
Definition / general
  • Longer transcript of Bcl-x
  • Protects cells from apoptosis (i.e. anti-apoptotic marker)
  • Relative amounts of pro- and anti-survival BCL2 family of proteins determine if cell will undergo cell death - if more Bcl-xL is present, pores are non-permeable and the cell survives (Wikipedia)
Diagrams / tables

Signal transduction pathways

Clinical features
Interpretation
  • Cytoplasmic staining; colon carcinoma cells serve as positive control
Uses by pathologists
Microscopic (histologic) images

Images hosted on Nature.com:

Diffuse large B cell lymphoma (fig F)

Ba: compound nevus is negative
Bb: melanoma >1.0 mm thick (times 400) is strongly positive
Bc: subcutaneous metastasis is positive

Positive staining - normal
Videos

Bcl-xL forms pore