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Table of Contents
Definition / generalCite this page: BCR-ABL. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbcrabl.html. Accessed July 12th, 2017.
Definition / general
- Protein fusion product formed by t(9;22)(q34;q11), called the Philadelphia chromosome
- Either p210 or p185 hybrid proteins
- p210 formed by bcr from 5' to b2/b3 of M (major)-bcr joined to second exon of c-abl (between IA and IB); has constitutive tyrosine kinase activity; associated with chronic myelogenous leukemia
- p185 formed by bcr from 5' to m (minor)-bcr; more potent tyrosine kinase than p210; associated with ALL or AML
- abl overexpression causes resistance to apoptosis induced by Fas, ceramide or chemotherapy
- Found in 25% adult ALL, 5% pediatric ALL; 95%+ of patients with CML
- Poor prognostic factor in pediatric ALL
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