Stains
BCR-ABL

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c)2003-2015, PathologyOutlines.com, Inc.

PubMed Search: bcr-abl[title]
Table of Contents
Definition / General
Cite this page: BCR-ABL. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbcrabl.html. Accessed December 9th, 2016.
Definition / General
  • Protein fusion product formed by t(9;22)(q34;q11), called the Philadelphia chromosome
  • Either p210 or p185 hybrid proteins
  • p210 formed by bcr from 5' to b2/b3 of M (major)-bcr joined to second exon of c-abl (between IA and IB); has constitutive tyrosine kinase activity; associated with chronic myelogenous leukemia
  • p185 formed by bcr from 5' to m (minor)-bcr; more potent tyrosine kinase than p210; associated with ALL or AML
  • abl overexpression causes resistance to apoptosis induced by Fas, ceramide or chemotherapy
  • Found in 25% adult ALL, 5% pediatric ALL; 95%+ of patients with CML
  • Poor prognostic factor in pediatric ALL