Beclin1 (Beclin-1)

Author: Nat Pernick, M.D.

Revised: 28 March 2018, last major update August 2015

Copyright: (c) 2003-2018,, Inc.

PubMed Search: beclin1
Page views in 2018: 55
Page views in 2019 to date: 1
Cite this page: Pernick, N. Beclin1. website. Accessed January 22nd, 2019.
Definition / general
  • Also known as autophagy-related gene 6 (Atg6)
  • 60kDa coiled coil protein that binds with bcl2 (Am J Cancer Res 2012;2:214)
  • Tumor suppressor on #17q21; frequently monoallelically lost in human cancers
  • Beclin1 and class III phosphoinositide 3-kinase (PI3K), its binding partner, are required to initiate formation of autophagosome in autophagy
Clinical features
Diagrams / tables

Autophagy and role of Beclin1 and bcl2

Microscopic (histologic) images

Images hosted on other servers:

Breast: normal and invasive ductal carcinoma

Colorectum: normal and carcinoma

Esophagus: normal and squamous cell carcinoma

Stomach: normal and inflamed gastric mucosa

Positive staining - normal
Positive staining - disease
  • Various carcinomas
Electron microscopy images

Disruption of beclin 1 causes autophagy deficiency
(left: normal, right: beclin 1 deficiency)