Stains
Beclin1 (Beclin-1)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 October 2015, last major update August 2015

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: beclin1
Cite this page: Beclin1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbeclin1.html. Accessed December 7th, 2016.
Definition / General
  • Also known as autophagy-related gene 6 (Atg6)
  • 60kDa coiled coil protein that binds with bcl2 (Am J Cancer Res 2012;2:214)
  • Tumor suppressor on #17q21; frequently monoallelically lost in human cancers
  • Beclin1 and class III phosphoinositide 3-kinase (PI3K), its binding partner, are required to initiate formation of autophagosome in autophagy
Clinical Features
Diagrams / Tables

Autophagy and role of Beclin1 and bcl2

Micro Images

Images hosted on other servers:

Breast: normal and invasive ductal carcinoma

Colorectum: normal and carcinoma

Esophagus: normal and squamous cell carcinoma

Stomach: normal and inflamed gastric mucosa



Images hosted on Nature.com:

Eye: uveal melanoma

Lymphomas: various

Positive Staining - Normal
Positive Staining - Disease
  • Various carcinomas
Electron Microscopy Images

Disruption of beclin 1 causes autophagy deficiency
(left: normal, right: beclin 1 deficiency)