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Beclin1 (Beclin-1)

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 15 April 2013, last major update April 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.


● Also known as autophagy-related gene 6 (Atg6)
● 60kDa coiled coil protein that binds with bcl2 (Am J Cancer Res 2012;2:214)
● Tumor suppressor on #17q21; frequently monoallelically lost in human cancers
● Beclin1 and class III phosphoinositide 3-kinase (PI3K), its binding partner, are required to initiate formation of autophagosome in autophagy

Clinical features

● Overexpressed in many human cancers; deleted in other cancers
● Reduced Beclin1 expression is poor prognostic factor: gastric carcinoma (Autophagy 2012;8:389), lymphoma (Mod Pathol 2010;23:937), pulmonary squamous cell and adenocarcinoma (Hum Pathol 2012;43:62)
● Reduced Beclin1 expression is favorable progostic factor: advanced colorectal cancer treated with cetuximab-containing chemotherapy (World J Gastroenterol 2011;17:4779), uveal melanoma (Mod Pathol 2011;24:1036)
● Herpesviruses, HIV and influenza A virus bind to Beclin1 to block autophagosome fusion with lyososomes (Viruses 2011;3:1166, J Virol 2012;86:2571)


Autophagy and role of Beclin1 and bcl2

Micro images

Breast: normal and invasive ductal carcinoma

Colorectum: normal and carcinoma

Esophagus: normal and squamous cell carcinoma

Eye: uveal melanoma

Lymphomas: various

Stomach: normal and inflamed gastric mucosa

Positive staining - normal

● Breast epithelium, cervix (Eur J Gynaecol Oncol 2012;33:15)

Positive staining - disease

● Various carcinomas

Electron microscopy images

Disruption of beclin 1 causes autophagy deficiency (left: normal, right: beclin 1 deficiency)

End of Stains > Beclin1

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