Stains
Beclin1 (Beclin-1)



Topic Completed: 1 August 2015

Revised: 4 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: beclin1
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Cite this page: Pernick N. Beclin1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbeclin1.html. Accessed March 25th, 2019.
Definition / general
  • Also known as autophagy-related gene 6 (Atg6)
  • 60kDa coiled coil protein that binds with bcl2 (Am J Cancer Res 2012;2:214)
  • Tumor suppressor on #17q21; frequently monoallelically lost in human cancers
  • Beclin1 and class III phosphoinositide 3-kinase (PI3K), its binding partner, are required to initiate formation of autophagosome in autophagy
Clinical features
Diagrams / tables

Autophagy and role of Beclin1 and bcl2

Microscopic (histologic) images

Images hosted on other servers:

Breast: normal and invasive ductal carcinoma

Colorectum: normal and carcinoma

Esophagus: normal and squamous cell carcinoma

Stomach: normal and inflamed gastric mucosa


Positive staining - normal
Positive staining - disease
  • Various carcinomas
Electron microscopy images

Disruption of beclin 1 causes autophagy deficiency
(left: normal, right: beclin 1 deficiency)

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