Beclin1 (Beclin-1)

Topic Completed: 1 August 2015

Minor changes: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: beclin1

Nat Pernick, M.D.
Page views in 2019: 61
Page views in 2020 to date: 16
Cite this page: Pernick N. Beclin1. website. Accessed June 1st, 2020.
Definition / general
  • Also known as autophagy-related gene 6 (Atg6)
  • 60kDa coiled coil protein that binds with bcl2 (Am J Cancer Res 2012;2:214)
  • Tumor suppressor on #17q21; frequently monoallelically lost in human cancers
  • Beclin1 and class III phosphoinositide 3-kinase (PI3K), its binding partner, are required to initiate formation of autophagosome in autophagy
Clinical features
Diagrams / tables

Autophagy and role of Beclin1 and bcl2

Microscopic (histologic) images

Images hosted on other servers:

Breast: normal and invasive ductal carcinoma

Colorectum: normal and carcinoma

Esophagus: normal and squamous cell carcinoma

Stomach: normal and inflamed gastric mucosa

Positive staining - normal
Positive staining - disease
  • Various carcinomas
Electron microscopy images

Disruption of beclin 1 causes autophagy deficiency
(left: normal, right: beclin 1 deficiency)

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