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Stains
Beta-catenin

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 13 July 2013, last major update July 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Physiology
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Clinical features
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Diagrams
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Cadherins and catenins in signal transduction

Role of β-catenin in cell

Uses by pathologists
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Micro images
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Bladder: urothelial carcinoma and adenocarcinoma

Breast: metaplastic carcinoma


Colon: serrated adenoma

Colon: normal and carcinoma


Liver: hepatoblastoma

Liver: metastatic colorectal carcinoma in sentinel lymph node and liver

Lung: lymphangio-leiomyomatosis


Neuroblastoma has strong cytoplasmic and membranous staining but no nuclear staining


Ovary: endometrioid carcinoma

PNET, rhabdomyosarcoma, nephroblastoma are β-catenin+

Soft tissue: liposarcoma

Soft tissue: solitary fibrous tumor

Synovial sarcoma

Positive staining - normal
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Positive staining - disease
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Negative staining
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End of Stains > Beta-catenin


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