Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 18 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Biotin[title]
- H&E shows optically clear nuclei or biotin-rich intranuclear inclusions; presence of biotin may cause false positive staining with avidin-peroxidase method
Positive staining - normal
- Pregnancy-related endometrium
Positive staining - disease
- Granulosa cell tumor-like variant of endometrioid carcinoma of ovary; also endometriotic cysts, morule-forming endometrioid carcinoma
Granulosa cell tumor-like variant of endometrioid carcinoma of ovary (figure 2C)
End of Stains > Biotin
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