Pathology Outlines

Stains
Biotin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: biotin[title]

Table of Contents

Interpretation | Positive staining - normal | Positive staining - disease | Microscopic (histologic) images

Cite this page: Biotin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbiotin.html. Accessed July 12th, 2017.

Interpretation

H&E shows optically clear nuclei or biotin-rich intranuclear inclusions; presence of biotin may cause false positive staining with avidin-peroxidase method

Positive staining - normal

Pregnancy-related endometrium

Positive staining - disease

Granulosa cell tumor-like variant of endometrioid carcinoma of ovary; also endometriotic cysts, morule-forming endometrioid carcinoma

Microscopic (histologic) images

Granulosa cell tumor-like variant of endometrioid carcinoma of ovary (figure 2C)