Stains
Biotin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

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PubMed Search: biotin[title]
Interpretation
  • H&E shows optically clear nuclei or biotin-rich intranuclear inclusions; presence of biotin may cause false positive staining with avidin-peroxidase method
Positive Staining - Normal
  • Pregnancy-related endometrium
Positive Staining - Disease
  • Granulosa cell tumor-like variant of endometrioid carcinoma of ovary; also endometriotic cysts, morule-forming endometrioid carcinoma
Micro Images

Granulosa cell tumor-like variant of endometrioid carcinoma of ovary (figure 2C)