Stains
Biotin



Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: biotin[title]
Page views in 2018: 29
Page views in 2019 to date: 18
Cite this page: Pernick N. Biotin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbiotin.html. Accessed March 23rd, 2019.
Interpretation
  • H&E shows optically clear nuclei or biotin-rich intranuclear inclusions; presence of biotin may cause false positive staining with avidin-peroxidase method
Positive staining - normal
  • Pregnancy-related endometrium
Positive staining - disease
  • Granulosa cell tumor-like variant of endometrioid carcinoma of ovary; also endometriotic cysts, morule-forming endometrioid carcinoma
Microscopic (histologic) images

Granulosa cell tumor-like variant of endometrioid carcinoma of ovary (figure 2C)

Back to top