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Table of Contents
Definition / GeneralDefinition / General
- Bone Morphogenetic Proteins
- Members of transforming growth factor-beta (TGF-beta) superfamily (20 types cloned through October 2005)
- Used for intercellular signals including cell growth and differentiation
- Ubiquitous in embryonic development; also involved in apoptosis
- Blocking their activity in chickens leads to duck feet
- Deletion causes lack of mesoderm development, lack of sperm development, eye/kidney deformities, misshapen feet
- Overexpression associated with fibrodysplasia ossificans progressiva, various bone and soft tissue sarcomas
- Colonic adenocarcinoma: BMP5 and BMP6 prominent in cytoplasm of tumor cells, BMP2 and BMP4 strongly expressed in surrounding mesenchymal cells
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