Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: BMP[title]

Nat Pernick, M.D.
Page views in 2018: 61
Page views in 2019 to date: 65
Table of Contents
Definition / general
Cite this page: Pernick N. BMP. website. Accessed September 18th, 2019.
Definition / general
  • Bone Morphogenetic Proteins
  • Members of transforming growth factor-beta (TGF-beta) superfamily (20 types cloned through October 2005)
  • Used for intercellular signals including cell growth and differentiation
  • Ubiquitous in embryonic development; also involved in apoptosis
  • Blocking their activity in chickens leads to duck feet
  • Deletion causes lack of mesoderm development, lack of sperm development, eye/kidney deformities, misshapen feet
  • Overexpression associated with fibrodysplasia ossificans progressiva, various bone and soft tissue sarcomas
  • Colonic adenocarcinoma: BMP5 and BMP6 prominent in cytoplasm of tumor cells, BMP2 and BMP4 strongly expressed in surrounding mesenchymal cells
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