Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 October 2015, last major update October 2013

Copyright: (c)2003-2015,, Inc.

PubMed Search: BMP[title]
Table of Contents
  • Bone Morphogenetic Proteins
  • Members of transforming growth factor-beta (TGF-beta) superfamily (20 types cloned through October 2005)
  • Used for intercellular signals including cell growth and differentiation
  • Ubiquitous in embryonic development; also involved in apoptosis
  • Blocking their activity in chickens leads to duck feet
  • Deletion causes lack of mesoderm development, lack of sperm development, eye/kidney deformities, misshapen feet
  • Overexpression associated with fibrodysplasia ossificans progressiva, various bone and soft tissue sarcomas
  • Colonic adenocarcinoma: BMP5 and BMP6 prominent in cytoplasm of tumor cells, BMP2 and BMP4 strongly expressed in surrounding mesenchymal cells