Pathology Outlines

Stains
BMP

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 October 2015, last major update October 2013

Copyright: (c)2003-2015, PathologyOutlines.com, Inc.

PubMed Search: BMP[title]

Table of Contents

Definition / general

Cite this page: BMP. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbmp.html. Accessed October 16th, 2018.

Definition / general

Bone Morphogenetic Proteins
Members of transforming growth factor-beta (TGF-beta) superfamily (20 types cloned through October 2005)
Used for intercellular signals including cell growth and differentiation
Ubiquitous in embryonic development; also involved in apoptosis
Blocking their activity in chickens leads to duck feet
Deletion causes lack of mesoderm development, lack of sperm development, eye/kidney deformities, misshapen feet
Overexpression associated with fibrodysplasia ossificans progressiva, various bone and soft tissue sarcomas
Colonic adenocarcinoma: BMP5 and BMP6 prominent in cytoplasm of tumor cells, BMP2 and BMP4 strongly expressed in surrounding mesenchymal cells