Topic Completed: 1 August 2015

Revised: 21 August 2019

Copyright: 2003-2019,, Inc.

PubMed Search: BOB1

Nat Pernick, M.D.
Page views in 2018: 2,806
Page views in 2019 to date: 2,611
Cite this page: Pernick N. BOB1. website. Accessed October 22nd, 2019.
Definition / general
  • B cell specific Octamer Binding protein-1
Pathophysiology / etiology
  • B cell transcription factor
  • Coactivator of OCT-2
  • Appears to mediate antigen-dependent germinal center formation
Uses by pathologists
  • Identify B cells in germinal centers, mantle cells and lymphomas
  • Determine lineage of CD20 negative B cell neoplasms (Am J Clin Pathol 2006;126:534)
  • Help differentiate classical Hodgkin's lymphoma (BOB1 negative) from primary mediastinal large B-cell lymphoma (positive, Histopathology 2010;56:217)
Microscopic (histologic) images

Images hosted on other servers:

Normal tonsil

Various B cell lymphomas

Positive staining - normal
Positive staining - disease
Negative staining
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