Author: Nat Pernick, M.D.

Revised: 30 March 2018, last major update August 2015

Copyright: (c) 2003-2018,, Inc.

PubMed Search: BOB.1
Page views in 2018: 2,806
Page views in 2019 to date: 516
Cite this page: Pernick, N. BOB.1. website. Accessed February 16th, 2019.
Definition / general
  • B cell specific Octamer Binding protein-1
Pathophysiology / etiology
  • B cell transcription factor
  • Coactivator of OCT-2
  • Appears to mediate antigen-dependent germinal center formation
Uses by pathologists
  • Identify B cells in germinal centers, mantle cells and lymphomas
  • Determine lineage of CD20 negative B cell neoplasms (Am J Clin Pathol 2006;126:534)
  • Help differentiate classical Hodgkin's lymphoma (BOB.1 negative) from primary mediastinal large B-cell lymphoma (positive, Histopathology 2010;56:217)
Microscopic (histologic) images

Images hosted on other servers:

Normal tonsil

Various B cell lymphomas

Positive staining - normal
Positive staining - disease
Negative staining