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Stains

BOB.1


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 November 2011, last major update November 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Terminology
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B cell specific Octamer Binding protein-1

Pathophysiology
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● B cell transcription factor
● Coactivator of OCT-2
● Appears to mediate antigen-dependent germinal center formation

Uses by pathologists
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● Identify B cells in germinal centers, mantle cells and lymphomas
● Determine lineage of CD20 negative B cell neoplasms (Am J Clin Pathol 2006;126:534)
● Help differentiate classical Hodgkin's lymphoma (BOB.1 negative) from primary mediastinal large B-cell lymphoma (positive, Histopathology 2010;56:217)

Micro images
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Normal tonsil

           
Various B cell lymphomas

Positive staining-normal
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● B cells, normal hematopoietic elements (weak staining, Am J Clin Pathol 2006;126:916)

Positive staining-disease
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● B cell lymphoma (germinal center derived, Am J Pathol 2000;156:501), lymphocyte predominant Hodgkin lymphoma (Mod Pathol 2006;19:1010), T cell lymphoma, AML (~ 48%)

Negative staining
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● Classic Hodgkin lymphoma (may have weak staining, Mod Pathol 2004;17:1531, but see Diagn Pathol 2007;2:10)

End of Stains > BOB.1


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