Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 August 2015, last major update November 2011

Copyright: (c) 2003-2015,, Inc.

PubMed Search: BOB.1
  • B cell specific Octamer Binding protein-1
Pathophysiology / Etiology
  • B cell transcription factor
  • Coactivator of OCT-2
  • Appears to mediate antigen-dependent germinal center formation
Uses by Pathologists
  • Identify B cells in germinal centers, mantle cells and lymphomas
  • Determine lineage of CD20 negative B cell neoplasms (Am J Clin Pathol 2006;126:534)
  • Help differentiate classical Hodgkin's lymphoma (BOB.1 negative) from primary mediastinal large B-cell lymphoma (positive, Histopathology 2010;56:217)
Micro Images

    Normal tonsil

    Various B cell lymphomas

Positive Staining - Normal
Positive Staining - Disease
Negative Staining