Stains
BOB.1

Author: Nat Pernick, M.D.

Revised: 30 March 2018, last major update August 2015

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: BOB.1
Cite this page: Pernick, N. BOB.1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbob1.html. Accessed June 21st, 2018.
Definition / general
  • B cell specific Octamer Binding protein-1
Pathophysiology / etiology
  • B cell transcription factor
  • Coactivator of OCT-2
  • Appears to mediate antigen-dependent germinal center formation
Uses by pathologists
  • Identify B cells in germinal centers, mantle cells and lymphomas
  • Determine lineage of CD20 negative B cell neoplasms (Am J Clin Pathol 2006;126:534)
  • Help differentiate classical Hodgkin's lymphoma (BOB.1 negative) from primary mediastinal large B-cell lymphoma (positive, Histopathology 2010;56:217)
Microscopic (histologic) images

Images hosted on other servers:

Normal tonsil

Various B cell lymphomas


Positive staining - normal
Positive staining - disease
Negative staining