Stains & CD markers
BOB1
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: BOB1
BOB1
Author: Nat Pernick, M.D.
Last author update: 1 August 2015
Last staff update: 23 June 2021
Copyright: 2003-2024, PathologyOutlines.com, Inc.
PubMed Search: BOB1
Table of Contents
Definition / general | Pathophysiology / etiology | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. BOB1. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsbob1.html. Accessed April 19th, 2024.
Definition / general
- B cell specific Octamer Binding protein-1
Pathophysiology / etiology
- B cell transcription factor
- Coactivator of OCT-2
- Appears to mediate antigen-dependent germinal center formation
Uses by pathologists
- Identify B cells in germinal centers, mantle cells and lymphomas
- Determine lineage of CD20 negative B cell neoplasms (Am J Clin Pathol 2006;126:534)
- Help differentiate classical Hodgkin's lymphoma (BOB1 negative) from primary mediastinal large B-cell lymphoma (positive, Histopathology 2010;56:217)
Microscopic (histologic) images
Images hosted on other servers:
Normal tonsil
Various B cell lymphomas
Positive staining - normal
- B cells, normal hematopoietic elements (weak staining, Am J Clin Pathol 2006;126:916)
Positive staining - disease
- B cell lymphoma (germinal center derived, Am J Pathol 2000;156:501), lymphocyte predominant Hodgkin lymphoma (Mod Pathol 2006;19:1010), T cell lymphoma, AML (~ 48%)
Negative staining
- Classic Hodgkin lymphoma (may have weak staining, Mod Pathol 2004;17:1531, but see Diagn Pathol 2007;2:10)
