Stains
Brachyury


Topic Completed: 1 January 2012

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: brachyury

Nat Pernick, M.D.
Page views in 2018: 1,181
Page views in 2019 to date: 1,004
Cite this page: Pernick N. Brachyury. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsbrachyury.html. Accessed August 22nd, 2019.
Definition / general
  • Transcription factor essential for notochordal cell differentiation, elongation of axis and specification of posterior mesodermal elements (Mod Pathol 2009;22:996)
Pathophysiology
  • Brachyury (T) is founding member of T box (Tbx) family
  • Transcriptional activator expressed throughout the nascent mesoderm, tailbud and notochord
  • Involved in the induction and regional specification of mesoderm
  • Brachyury deficient embryos lack tail and trunk structures and die shortly after gastrulation (PLoS One 2011;6:e28394)
  • In tumor cells, induces epithelial-mesenchymal transition, an important step in progression toward metastasis (J Clin Invest 2010;120:533)
Interpretation
  • Nuclear staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Chordoma and variants

Positive staining - normal
  • Spermatogonia
Positive staining - disease
Negative staining
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