Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 November 2015, last major update January 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: brachyury
Page views in 2018: 1,181
Page views in 2019 to date: 257
Cite this page: Brachyury. website. Accessed February 16th, 2019.
Definition / general
  • Transcription factor essential for notochordal cell differentiation, elongation of axis and specification of posterior mesodermal elements (Mod Pathol 2009;22:996)
  • Brachyury (T) is founding member of T box (Tbx) family
  • Transcriptional activator expressed throughout the nascent mesoderm, tailbud and notochord
  • Involved in the induction and regional specification of mesoderm
  • Brachyury deficient embryos lack tail and trunk structures and die shortly after gastrulation (PLoS One 2011;6:e28394)
  • In tumor cells, induces epithelial-mesenchymal transition, an important step in progression toward metastasis (J Clin Invest 2010;120:533)
  • Nuclear staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Chordoma and variants

Positive staining - normal
  • Spermatogonia
Positive staining - disease
Negative staining