Author: Nat Pernick, M.D. (see Authors page)

Revised: 17 November 2015, last major update January 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: brachyury
Definition / General
  • Transcription factor essential for notochordal cell differentiation, elongation of axis and specification of posterior mesodermal elements (Mod Pathol 2009;22:996)
  • Brachyury (T) is founding member of T box (Tbx) family
  • Transcriptional activator expressed throughout the nascent mesoderm, tailbud and notochord
  • Involved in the induction and regional specification of mesoderm
  • Brachyury deficient embryos lack tail and trunk structures and die shortly after gastrulation (PLoS One 2011;6:e28394)
  • In tumor cells, induces epithelial-mesenchymal transition, an important step in progression toward metastasis (J Clin Invest 2010;120:533)
  • Nuclear staining
Uses by Pathologists
Micro Images

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Chordoma and variants

Positive Staining - Normal
  • Spermatogonia
Positive Staining - Disease
Negative Staining