Author: Nat Pernick, M.D.

Revised: 30 March, 2018, last major update September 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: BUB1B
Cite this page: Pernick, N. BUB1B. website. Accessed July 21st, 2018.
Definition / general
  • BUB1B (Budding-uninhibited-by-benzimidazoles-1-homolog-beta), also called BUBR1 (budding uninhibited by benzimidazole-related (GeneCards)
  • Mitotic checkpoint kinase required for cell mitotic division following severe cell damage or mutation
  • Delay onset of anaphase until all chromosomes are properly bi-oriented on mitotic spindle (Trends Biochem Sci 2011;36:141)
  • Associated with cell proliferation in neoplastic and nonneoplastic tissues
  • Function is dosage dependent; reductions cause premature chromatid separation or aneuploidy, depending on magnitude of reduction (Hum Genet 2008;124:473)
Clinical features
Diagrams / tables

Images hosted on other servers:

Role in spindle checkpoint

Uses by pathologists
  • No specific uses for pathologists at this time
Microscopic (histologic) images

Images hosted on other servers:

Breast: histologically normal with low/high grade molecular abnormalities

Breast: invasive ductal carcinoma

Colon: normal, ulcerative colitis, carcinoma

Nasopharyngeal carcinoma

Ovary: carcinoma

Testes: normal, seminoma, embryonal carcinoma