Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: cadherins[title]
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Table of Contents
Definition / general
Cite this page: Cadherins. website. Accessed January 19th, 2019.
Definition / general
  • See also E-cadherin, N-cadherin
  • Molecules that establish links between adjacent cells by forming zipper like structures at adherens junctions
  • Linked to cytoskeleton via catenins (cadherin to beta catenin, beta catenin to alpha catenin, alpha catenin to actin) to stabilize adherens junction
  • Homophilic interactions (like-like) causes clustering of embryonic cells with others from same tissue
  • Loss of cadherins may be first step in giving cells invasive properties