Stains
Cadherins

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: cadherins[title]
Table of Contents
Definition / General
Cite this page: Cadherins. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscadherins.html. Accessed December 8th, 2016.
Definition / General
  • See also E-cadherin, N-cadherin
  • Molecules that establish links between adjacent cells by forming zipper like structures at adherens junctions
  • Linked to cytoskeleton via catenins (cadherin to beta catenin, beta catenin to alpha catenin, alpha catenin to actin) to stabilize adherens junction
  • Homophilic interactions (like-like) causes clustering of embryonic cells with others from same tissue
  • Loss of cadherins may be first step in giving cells invasive properties