Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 October 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: calponin[title]
Definition / General
  • Actin filament associated regulatory protein
  • h1 (basic) isoform is smooth muscle specific, but a late stage smooth muscle marker; described below
  • h2 isoform is found in smooth muscle and non muscle cells; not described below
Uses by Pathologists
Positive Staining - Normal
Positive Staining - Disease
Negative Staining
  • Adenoid cystic carcinoma
Micro Images

Images hosted on Pathout server:

Sclerosing lobular hyperplasia

Images hosted on other servers:


Adenomyoepithelioma (fig I)

Salivary gland-

Adenoid cystic carcinoma-
submandibular gland

Epithelial-myoepithelial carcinoma


Hidradenoma papilliferum

MFH of bone (fig B, F)

Pleomorphic adenoma of nasal cavity (fig 4B)

Images hosted on

Phyllodes tumor-malignant, metastatic (fig D)

Basal cell adenoma

Adenoid cystic carcinoma (fig E)
versus collagenous spherulosis (fig J)