Author: Nat Pernick, M.D.

Revised: 26 April 2018, last major update October 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: calponin[title]
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Cite this page: Pernick, N. Calponin. website. Accessed August 24th, 2019.
Definition / general
  • Actin filament associated regulatory protein
  • h1 (basic) isoform is smooth muscle specific, but a late stage smooth muscle marker; described below
  • h2 isoform is found in smooth muscle and non muscle cells; not described below
Uses by pathologists
Microscopic (histologic) images

Images hosted on Pathout server:

Sclerosing lobular hyperplasia

Images hosted on other servers:


Adenomyoepithelioma (fig I)

Salivary gland

Epithelial-myoepithelial carcinoma


MFH of bone (fig B, F)

Pleomorphic adenoma of nasal cavity (fig 4B)

Positive staining - normal
Positive staining - disease
Negative staining
  • Adenoid cystic carcinoma
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