Cytokeratin CAM 5.2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update May 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CAM 5.2[title]
Definition / General
  • Commonly used antibody to cytokeratins 8 and to a lesser extent CK7, but not to cytokeratin 18 or 19 (Am J Clin Pathol 2010;133:514)
  • A low molecular weight cytokeratin
Uses by Pathologists
Micro Images

Images hosted on other servers:

Breast: left-normal, right-carcinoma

Breast: metaplastic carcinoma

Choroid plexus: papilloma-pigmented

Ovary: female adnexal tumor of wolffian origin (fig 3A)

Liver: Mallory bodies in acute alcoholic hepatitis (fig 3)

Pancreas: ductal adenocarcinoma

Skin: dermatopathic lymphadenitis (dendritic cells are CAM 5.2+)

Squamous cell carcinoma is CAM5.2 negative (fig 7-left side) but basal cell carcinoma is CAM 5.2+ (fig 7-right side)

Quality control-various images

Images hosted on
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Bladder: osteoclast-like giant cell carcinoma of urinary tract

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CNS: gliosarcoma with epithelial differentiation (fig 3A)

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Skin: Merkel cell carcinoma (fig C)

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Soft tissue: desmoplastic small round cell tumor

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Small cell carcinoma: dot like staining

Positive Staining - Normal
Positive Staining - Disease
Negative Staining