Stains
Caspase 3

Author: Nat Pernick, M.D.

Revised: 1 May 2018, last major update February 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: caspase 3[title]

Caspases topics: General, Caspase 7, Caspase 8, Caspase 9

Cite this page: Pernick, N. Caspase 3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscaspase3.html. Accessed October 15th, 2018.
Definition / general
  • Final common pathway effector caspase that carries out apoptosis; its presence means that apoptosis has not only been initiated but also occurred
  • Interacts with upstream caspases 8 and 9 (Wikipedia)
  • Cleaves PARP and ICAD
  • Cleaved caspase 3 (CCP-3) is the large fragment (17/19 kDa) of activated caspase 3 resulting from cleavage adjacent to Asp175; may have prognostic value if present in >10% of tumor cells in some malignancies
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Detection of cleaved caspase 3

Cleaved caspase 3 in granular cell tumors