Cite this page: Pernick, N. Caspase 3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscaspase3.html. Accessed January 22nd, 2019.
Definition / general
- Final common pathway effector caspase that carries out apoptosis; its presence means that apoptosis has not only been initiated but also occurred
- Interacts with upstream caspases 8 and 9 (Wikipedia)
- Cleaves PARP and ICAD
- Cleaved caspase 3 (CCP-3) is the large fragment (17/19 kDa) of activated caspase 3 resulting from cleavage adjacent to Asp175; may have prognostic value if present in >10% of tumor cells in some malignancies
Uses by pathologists
- Immunohistochemical marker of apoptosis (J Histochem Cytochem 2002;50:449)