Caspase 8

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update February 2012

Copyright: (c) 2003-2015,, Inc.

PubMed Search: caspase 8[title]

Caspases topics: General, Caspase 3, Caspase 7, Caspase 9

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Cite this page: Caspase 8. website. Accessed January 19th, 2019.
Definition / general
  • Initiator caspase, also cleaves Bid, a bcl2 homolog that activates caspase 9 by releasing cytochrome C from mitochondria
  • Has important role in CD95-mediated activation of MAPKs (Cell Death Dis 2011;2:e212)
Uses by pathologists
  • Marker of initiation of apopotosis