Cite this page: Caspase 8. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscaspase8.html. Accessed August 15th, 2018.
Definition / general
- Initiator caspase, also cleaves Bid, a bcl2 homolog that activates caspase 9 by releasing cytochrome C from mitochondria
- Has important role in CD95-mediated activation of MAPKs (Cell Death Dis 2011;2:e212)
Uses by pathologists
- Marker of initiation of apopotosis