Cathepsin K

Topic Completed: 1 July 2013

Revised: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: cathepsin k

Nat Pernick, M.D.
Page views in 2018: 814
Page views in 2019 to date: 711
Cite this page: Pernick N. Cathepsin K. website. Accessed September 17th, 2019.
Definition / general
  • Lysosomal, papain-like cysteine protease with high matrix-degrading activity; expression is driven by microphthalmia transcription factor (MITF) in osteoclasts
  • Responsible for bone resorption and remodeling
  • Germline mutations cause sclerosing osteochondrodysplasia pycnodysostosis, a rare autosomal recessive skeletal dysplasia characterized by abnormal bone and tooth development
Uses by pathologists
  • Diagnosis of renal angiomyolipoma and other renal erivascular epithelioid cell tumors (Mod Pathol 2012;25:100)
Microscopic (histologic) images

Images hosted on other servers:

Bone: osteoclasts in osteoclastoma and normal

Intervertebral disc

Maxillary sinus: basaloid squamous cell carcinoma

Positive staining - normal
Positive staining - disease
Negative staining
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