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Stains

CCR1


Reviewers: Nat Pernick, M.D. (see Reviewers page)
Revised: 24 January 2012, last major update January 2012
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

General
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● Member of beta chemokine receptor family; its major ligands are CCL3/MIP-1α, CCL5/RANTES and CCL7/MCP-3 (PLoS One 2011;6:e21772)

Terminology
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● Also called chemokine C-C motif receptor 1, CD191
● Note: maize protein cinnamoyl-CoA reductase 1 is also called CCR1 (J Exp Bot 2011;62:3837)

Clinical features
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● Participates in pathogenesis of several renal diseases by orchestrating myeloid cell kidney infiltration (Am J Pathol 2011 Dec 24 [Epub ahead of print])
● May play an important role in multiple myeloma (Future Med Chem 2011;3:1889)
● Antagonists are being developed for use in rheumatoid arthritis (Clin Pharmacol Ther 2011;89:726)

Diagrams
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The chemokine wheel


Allergens and viral infections in lung

Micro images
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Various leukemias / lymphomas

Positive stains
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● Monocytes/macrophages, neutrophils, lymphocytes, eosinophils, dendritic cells
● Basophils (Allergy 2006;61:1054)

End of Stains > CD191


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