Pathology Outlines

Stains
CCR1 (CD191)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update January 2012

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CCR1[title]

Table of Contents

Cite this page: CCR1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr1.html. Accessed July 12th, 2017.

Definition / general

Member of beta chemokine receptor family; its major ligands are CCL3/MIP-1α, CCL5/RANTES and CCL7/MCP-3 (PLoS One 2011;6:e21772)

Terminology

Also called chemokine C-C motif receptor 1, CD191
Note: maize protein cinnamoyl-CoA reductase 1 is also called CCR1 (J Exp Bot 2011;62:3837)

Clinical features

Participates in pathogenesis of several renal diseases by orchestrating myeloid cell kidney infiltration (Am J Pathol 2012;180:1040)
May play an important role in multiple myeloma (Future Med Chem 2011;3:1889)
Antagonists are being developed for use in rheumatoid arthritis (Clin Pharmacol Ther 2011;89:726)

Diagrams / tables

Images hosted on Nature.com:

The chemokine wheel

Microscopic (histologic) images

Various leukemias / lymphomas

Positive stains

Monocytes/macrophages, neutrophils, lymphocytes, eosinophils, dendritic cells
Basophils (Allergy 2006;61:1054)