Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 July 2012, last major update July 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
● Receptor for MCP1, MCP3, MCP4 chemokines; alternative coreceptor with CD4 for HIV1
● Abbreviation for chemokine C-C motif ligand 2 (CCL2)-chemokine C-C motif receptor 2
● Also known as CD192, but most publications use CCR2
● Inflammatory cytokine with 374 amino acids that mediates biologic effects of CCL2, also known as monocyte chemoattractant protein 1 (MCP1); CCL2-CCR2 may be involved in neuroinflammation and chronic pain (J Neuroinflammation 2012;9:136); but in astrocytes, CCL2 binding may be CCR2 independent (Brain Res 2012;1437:115)
● During chemotaxis, may act as scavenger consuming the chemokine (PLoS One 2012;7:e37208)
● Reduced levels in peripheral blood mononuclear cells in patients with amyotrophic lateral sclerosis (PLoS One 2012;7:e38382)
● Mutations associated with reduced risk for severe coronary artery disease (Intern Med 2011;50:2457), delay in progression of HIV to AIDS (AIDS 2000;14:483)
● Mutations associated with increased risk for osteoporosis and osteopenia (Genet Test Mol Biomarkers 2012;16:229), chronic renal failure (Intern Med 2011;502457:649), oral cancer (Oral Oncol 2011;47:577)
Uses by pathologists
● No specific uses by pathologists
Lamina propria lymphocytes in small bowel Crohn’s disease and control ileum
Positive staining - normal
● Neurons, monocytes
● Controversial if expressed on microglia, or due to infiltrating monocytes
End of Stains > CCR2
Ref Updated: 7/6/12
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