Advertisement
Advertisement
Table of Contents
Definition / general | Terminology | Clinical features | Uses by pathologists | Microscopic (histologic) images | Positive staining - normalCite this page: CCR2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr2.html. Accessed July 12th, 2017.
Definition / general
- Receptor for MCP1, MCP3, MCP4 chemokines; alternative coreceptor with CD4 for HIV1
Terminology
- Abbreviation for chemokine C-C motif ligand 2 (CCL2)-chemokine C-C motif receptor 2
- Also known as CD192, but most publications use CCR2
Clinical features
- Inflammatory cytokine with 374 amino acids that mediates biologic effects of CCL2, also known as monocyte chemoattractant protein 1 (MCP1); CCL2-CCR2 may be involved in neuroinflammation and chronic pain (J Neuroinflammation 2012;9:136); but in astrocytes, CCL2 binding may be CCR2 independent (Brain Res 2012;1437:115)
- During chemotaxis, may act as scavenger consuming the chemokine (PLoS One 2012;7:e37208)
- Reduced levels in peripheral blood mononuclear cells in patients with amyotrophic lateral sclerosis (PLoS One 2012;7:e38382)
- Mutations associated with reduced risk for severe coronary artery disease (Intern Med 2011;50:2457), delay in progression of HIV to AIDS (AIDS 2000;14:483)
- Mutations associated with increased risk for osteoporosis and osteopenia (Genet Test Mol Biomarkers 2012;16:229), chronic renal failure (Intern Med 2011;502457:649), oral cancer (Oral Oncol 2011;47:577)
Uses by pathologists
- No specific uses by pathologists
Microscopic (histologic) images
Human glomeruli
Lamina propria lymphocytes in small bowel Crohn’s disease and control ileum
Positive staining - normal
- Neurons, monocytes
- Controversial if expressed on microglia, or due to infiltrating monocytes
Advertisement
