CCR3 (CD193)

Author: Nat Pernick, M.D.

Revised: 21 August 2018, last major update October 2012

Copyright: (c) 2003-2018, Inc.

PubMed Search: CCR3[title]
Cite this page: Pernick, N. CCR3. website. Accessed November 21st, 2018.
Definition / general
  • C-C chemokine receptor type 3; also known as CD193
  • G protein-coupled receptor for eotaxins
  • Marker for Th2 cells (type 2 helper T cells, which promote humoral immune system)
  • Constitutively expressed at high levels in eosinophils; primary chemokine receptor responsible for eosinophil recruitment to inflamed tissues (Exp Mol Med 2012;44:268)
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:


Eosinophils and airway epithelium

Lymph node: Hodgkin disease

Skin: cutaneous T cell lymphoma

Paraffin embedded malignant melanoma

Renal cell carcinoma

Positive staining - normal
  • Bronchial smooth muscle and epithelium (Clin Exp Allergy 2012;42:1040)
  • Eosinophils, basophils, mast cells
  • Th2 helper cells
  • Epidermal keratinocytes and dermal fibroblasts
Positive staining - disease