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Stains

CCR3


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 14 October 2012, last major update October 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

General
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● C-C chemokine receptor type 3; also known as CD193
● G protein-coupled receptor for eotaxins
● Marker for Th2 cells (type 2 helper T cells, which promote humoral immune system)
● Constitutively expressed at high levels in eosinophils; primary chemokine receptor responsible for eosinophil recruitment to inflamed tissues (Exp Mol Med 2012;44:268)

Clinical features
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● May play an integral role in pathogenesis of allergic diseases including asthma, allergic dermatitis, allergic rhinitis (Respir Res 2010;11:17); important drug target for inflammatory diseases
● May also play a role in neovascular age-related macular degeneration (Invest Ophthalmol Vis Sci 2011;52:8271, J Mol Cell Biol 2009;1:17), ulcerative colitis (Clin Exp Immunol 2010;162:337)
● CCR3 expression on peripheral blood lymphocytes is associated with EBV related infectious mononucleosis (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2010;24:355)
● CCR3 gene polymorphisms may contribute to aspirin exacerbated respiratory disease (Respir Med 2010;104:626)

Uses by pathologists
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● Possible basophil selection marker for flow cytometry (Allergy 2011;66:85, but see Cytometry A 2011;79:102)

Micro images
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Atherosclerosis


Eosinophils and airway epithelium


Lymph node: Hodgkin disease


Skin: keratinocytes in normal skin and bullous pemphigoid

   
Skin: cutaneous T cell lymphoma (left), cutaneous or nodal peripheral T cell lymphoma NOS (right)


Skin: melanoma, squamous cell carcinoma, basal cell carcinoma, normal


Renal cell carcinoma


Uterus: endometrium

Positive staining - normal
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● Bronchial smooth muscle and epithelium (Clin Exp Allergy 2012;42:1040)
● Eosinophils, basophils, mast cells
● Th2 helper cells
● Epidermal keratinocytes and dermal fibroblasts

Positive staining - disease
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● Cutaneous melanoma and squamous cell carcinoma (Ann Dermatol 2010;22:412)
● Cutaneous T cell lymphoma (J Invest Dermatol 2010;130:2304)

End of Stains > CCR3

Ref Updated: Ref Updated: 7/6/12


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