Pathology Outlines

Stains
CCR3 (CD193)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update October 2012,

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CCR3[title]

Table of Contents

Cite this page: CCR3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr3.html. Accessed July 12th, 2017.

Definition / general

C-C chemokine receptor type 3; also known as CD193
G protein-coupled receptor for eotaxins
Marker for Th2 cells (type 2 helper T cells, which promote humoral immune system)
Constitutively expressed at high levels in eosinophils; primary chemokine receptor responsible for eosinophil recruitment to inflamed tissues (Exp Mol Med 2012;44:268)

Clinical features

May play an integral role in pathogenesis of allergic diseases including asthma, allergic dermatitis, allergic rhinitis (Respir Res 2010;11:17); important drug target for inflammatory diseases
May also play a role in neovascular age-related macular degeneration (Invest Ophthalmol Vis Sci 2011;52:8271, J Mol Cell Biol 2009;1:17), ulcerative colitis (Clin Exp Immunol 2010;162:337)
CCR3 expression on peripheral blood lymphocytes is associated with EBV related infectious mononucleosis (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2010;24:355)
CCR3 gene polymorphisms may contribute to aspirin exacerbated respiratory disease (Respir Med 2010;104:626)

Uses by pathologists