CCR3 (CD193)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update October 2012,

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CCR3[title]
Cite this page: CCR3. website. Accessed April 23rd, 2017.
Definition / General
  • C-C chemokine receptor type 3; also known as CD193
  • G protein-coupled receptor for eotaxins
  • Marker for Th2 cells (type 2 helper T cells, which promote humoral immune system)
  • Constitutively expressed at high levels in eosinophils; primary chemokine receptor responsible for eosinophil recruitment to inflamed tissues (Exp Mol Med 2012;44:268)
Clinical Features
Uses by Pathologists
Micro Images

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Eosinophils and airway epithelium

Lymph node: Hodgkin disease

Skin: cutaneous T cell lymphoma (left), cutaneous or nodal peripheral T cell lymphoma NOS (right)

Skin: melanoma, squamous cell carcinoma, basal cell carcinoma, normal

Renal cell carcinoma

Uterus: endometrium

Images hosted on

Skin: keratinocytes in normal skin and bullous pemphigoid

Positive Staining - Normal
  • Bronchial smooth muscle and epithelium (Clin Exp Allergy 2012;42:1040)
  • Eosinophils, basophils, mast cells
  • Th2 helper cells
  • Epidermal keratinocytes and dermal fibroblasts
Positive Staining - Disease