Stains
CCR4 (CD194)

Author: Nat Pernick, M.D.

Revised: 21 August 2018, last major update April 2013

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CCR4[title]
Cite this page: Pernick, N. CCR4. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr4.html. Accessed November 21st, 2018.
Definition / general
  • CC chemokine receptor 4
  • Seven-transmembrane G-protein coupled receptor, selectively expressed on Th2 cells and regulatory T cells
  • CCR4-NOT deadenylase complex is key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation (Protein Cell 2011;2:755, FEBS Lett 2011;585:2182); catalyzes removal of mRNA poly(A) tails, repressing translation and committing mRNA to degradation (RNA Biol 2013;10(2):228)
  • Receptor for CCL2 (MCP-1), CCL4 (MIP-1), CCL5 (RANTES), CCL17 (TARC), CCL22 (Macrophage-derived chemokine) (Wikipedia-CCR4)
Clinical features
  • Tumor cells may function as Treg cells with CCR4 expression, contributing to tumor survival by downregulating host immunity; tumor cells also produce CCR4 ligands which attract other CCR4+ Treg cells to tumor site (Cancer Sci 2011;102:44)
  • Humanized anti-CCR4 monoclonal antibody, mogamulizumab (KW-0761), is being studied to treat peripheral T cell lymphoma (Curr Hematol Malig Rep 2012;7:235)
Uses by pathologists
  • No significant clinical uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Lymph node: normal

Lymph node and peripheral blood: adult T cell leukemia / lymphoma

Skin: S├ęzary Syndrome

Positive staining - normal
  • Th2 cells and regulatory T cells
Positive staining - disease