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Table of Contents
Definition / general | Clinical features | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: CCR4. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr4.html. Accessed July 12th, 2017.
Definition / general
- CC chemokine receptor 4
- Seven-transmembrane G-protein coupled receptor, selectively expressed on Th2 cells and regulatory T cells
- CCR4-NOT deadenylase complex is key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation (Protein Cell 2011;2:755, FEBS Lett 2011;585:2182); catalyzes removal of mRNA poly(A) tails, repressing translation and committing mRNA to degradation (RNA Biol 2013;10(2):228)
- Receptor for CCL2 (MCP-1), CCL4 (MIP-1), CCL5 (RANTES), CCL17 (TARC), CCL22 (Macrophage-derived chemokine) (Wikipedia-CCR4)
Clinical features
- Tumor cells may function as Treg cells with CCR4 expression, contributing to tumor survival by downregulating host immunity; tumor cells also produce CCR4 ligands which attract other CCR4+ Treg cells to tumor site (Cancer Sci 2011;102:44)
- Humanized anti-CCR4 monoclonal antibody, mogamulizumab (KW-0761), is being studied to treat peripheral T cell lymphoma (Curr Hematol Malig Rep 2012;7:235)
Uses by pathologists
- No significant clinical uses at this time
Microscopic (histologic) images
Images hosted on other servers:
Lymph node: normal
Lymph node and peripheral blood: adult T cell leukemia/lymphoma
Peripheral T cell lymphoma, unspecified
Skin: atopic dermatitis
Skin: cutaneous leishmaniasis
Skin: Sézary Syndrome
Images hosted on Nature.com:
Lymph node: Hodgkin lymphoma, nodular sclerosing
Skin: atopic dermatitis
Positive staining - normal
- Th2 cells and regulatory T cells
Positive staining - disease
- Carcinomas of breast (Breast Cancer Res Treat 2012;131:837), stomach (Cancer Sci 2011;102:1264)
- Lymphoma: anaplastic large cell lymphoma (60% of nodal ALK- tumors, Mod Pathol 2002;15:838), CLL in peripheral blood (low levels, Eur J Haematol 2011;87:80), peripheral T-cell lymphoma, including adult T cell leukemia/lymphoma (Am J Surg Pathol 2007;31:216), dermis-based lymphomas (Am J Surg Pathol 2006;30:1111)
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