CCR5 (CD195)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 20 November 2015, last major update April 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CCR5[title]
Cite this page: CCR5. website. Accessed October 15th, 2018.
Definition / general
  • Chemokine (C-C motif) receptor 5; also known as CD195
  • Surface receptor and attachment site for HIV and SIV into CD4+ cells, along with CXCR4 (CD184) (Exp Biol Med (Maywood) 2011;236:637); those with CCR5-Δ32 mutation may have HIV resistance (Wikipedia)
  • Receptor for CD8 chemokines RANTES, MIP 1-alpha, MIP 1-beta, monocyte chemoattractant protein 2 (MCP-2)
  • Also receptor for Staphylococcus aureus leukotoxin ED (Nature 2013;493:51)
Diagrams / tables

HIV entry into CD4+ cell via CCR5 co-receptor

Uses by pathologists
  • No uses at this time
Positive staining - normal
  • T cells, macrophages