Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 28 April 2013, last major update April 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
● Chemokine (C-C motif) receptor 5; also known as CD195
● Surface receptor and attachment site for HIV and SIV into CD4+ cells, along with CXCR4 (CD184) (Exp Biol Med (Maywood) 2011;236:637); those with CCR5-Δ32 mutation may have HIV resistance (Wikipedia)
● Receptor for CD8 chemokines RANTES, MIP 1-alpha, MIP 1-beta, monocyte chemoattractant protein 2 (MCP-2)
● Also receptor for Staphylococcus aureus leukotoxin ED (Nature 2013;493:51)
HIV entry into CD4+ cell via CCR5 co-receptor
Uses by pathologists
● No uses at this time
Positive staining - normal
● T cells, macrophages
End of Stains > CCR5
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