Stains
CCR5 (CD195)


Topic Completed: 1 April 2013

Revised: 12 September 2019

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PubMed Search: CCR5[title]

Nat Pernick, M.D.
Page views in 2018: 36
Page views in 2019 to date: 60
Cite this page: Pernick N. CCR5. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr5.html. Accessed September 23rd, 2019.
Definition / general
  • Chemokine (C-C motif) receptor 5; also known as CD195
  • Surface receptor and attachment site for HIV and SIV into CD4+ cells, along with CXCR4 (CD184) (Exp Biol Med (Maywood) 2011;236:637); those with CCR5-Δ32 mutation may have HIV resistance (Wikipedia)
  • Receptor for CD8 chemokines RANTES, MIP 1-alpha, MIP 1-beta, monocyte chemoattractant protein 2 (MCP-2)
  • Also receptor for Staphylococcus aureus leukotoxin ED (Nature 2013;493:51)
Diagrams / tables

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HIV entry into CD4+ cell via CCR5 co-receptor

Uses by pathologists
  • No uses at this time
Positive staining - normal
  • T cells, macrophages
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