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Table of Contents
Definition / general | Diagrams / tables | Clinical features | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: CCR7. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr7.html. Accessed July 12th, 2017.
Definition / general
- C-C chemokine receptor type 7
- Ligands are CCL19 and CCL21 (Wikipedia-C-C chemokine receptor type 7)
- Chemokine receptor that is 7 transmembrane domain G protein-coupled receptor
- Facilitates T cell migration to (J Immunol 2011;187:5645) and compartmentation within secondary lymph nodes (PLoS One 2011;6:e18183)
- Promotes cell proliferation via extracellular signal-regulated kinase (ERK) pathway; may prevent apoptosis by upregulating bcl2 and downregulating bax and caspase3 (PLoS One 2012;7:e33262)
Diagrams / tables
CCR7 function in regulatory T cells
Clinical features
- Aberrant CCR7 expression in various malignancies has been linked to pro-survival, -invasive, and -metastatic pathways (J Biol Chem 2012;287:3581)
- CCR7-CCL21 pathway may have role in rheumatoid arthritis angiogenesis (Arthritis Rheum 2012;64:2471)
- Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal (Hum Pathol 2009;40:1553)
- 85 year old man with primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma which transformed from indolent to aggressive phase in association with CCR7+ conversion (Dermatol Online J 2012;18:5)
Uses by pathologists
- Tumor infiltration by CCR7+ T cells may be favorable prognostic marker in advanced colorectal carcinoma (Clin Cancer Res 2012;18:850)
Microscopic (histologic) images
Images hosted on other servers:
Breast: various carcinomas
Cervix: squamous cell carcinoma and adenocarcinoma
Colorectum: T cells in advanced adenocarcinoma
Esophagus: squamous cell carcinoma and metastatic lymph node
Lymphoma-T cell
Oropharynx: squamous cell carcinomal
Skin: melanoma and sentinel lymph node
Positive staining - normal
- Dendritic cells (Mediators Inflamm 2012;2012:320953), macrophages (some), T lymphocytes (some, Oncoimmunology 2012;1:531, Am J Clin Pathol 2010;133:281)
Positive staining - disease
- Various carcinomas including breast (J Cell Physiol 2013;228:341), esophagus (Ann Surg Oncol 2012;19:3606), head and neck-squamous cell (J Biol Chem 2012;287:3581), lung (PLoS One 2012;7:e33262), melanoma (Microcirculation 2011;18:172, Hum Pathol 2007;38:768)
- MALT lymphoma and some diffuse large B cell lymphomas (Mod Pathol 2013;26:182)
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