Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2015, last major update March 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CCR7

CCR7 function in regulatory T cells

Clinical Features
  • Aberrant CCR7 expression in various malignancies has been linked to pro-survival, -invasive, and -metastatic pathways (J Biol Chem 2012;287:3581)
  • CCR7-CCL21 pathway may have role in rheumatoid arthritis angiogenesis (Arthritis Rheum 2012;64:2471)
  • Macrophages participate in lymphangiogenesis in idiopathic diffuse alveolar damage through CCL19-CCR7 signal (Hum Pathol 2009;40:1553)
  • 85 year old man with primary cutaneous aggressive epidermotropic CD8+ T cell lymphoma which transformed from indolent to aggressive phase in association with CCR7+ conversion (Dermatol Online J 2012;18:5)
Uses by Pathologists
  • Tumor infiltration by CCR7+ T cells may be favorable prognostic marker in advanced colorectal carcinoma (Clin Cancer Res 2012;18:850)
Micro Images

Images hosted on other servers:

Breast: various carcinomas

Cervix: squamous cell carcinoma and adenocarcinoma

Colorectum: T cells in advanced adenocarcinoma

Esophagus: squamous cell carcinoma and metastatic lymph node

Lymphoma-T cell

Oropharynx: squamous cell carcinomal

Skin: melanoma and sentinel lymph node

Positive Staining - Normal
Positive Staining - Disease