Pathology Outlines

Stains
CCR8 (CD198)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2015, last major update April 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CCR8

Table of Contents

Definition / general | Uses by pathologists | Positive staining - normal

Cite this page: CCR8. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsccr8.html. Accessed July 12th, 2017.

Definition / general

Chemokine (C-C motif) receptor 8; also known as CDw198
Chemokine receptor associated with asthma / allergic diseases via Th2 pathway
Ligand is CCL1 (Wikipedia)
Antagonists may have efficacy against asthma
May play a role in macrophage recruitment and activation in type 1 diabetes (J Immunol 2007;179:5760) and COPD (Clin Vaccine Immunol 2011;18:2050); also endometriosis (Fertil Steril 2007;88:317)
May be alternate coreceptor for HIV1 and HIV2 (Virology 2010;408:174)

Uses by pathologists

No uses at this time

Positive staining - normal

Dendritic cells (Biochem Pharmacol 2012;83:778), eosinophils, T cells (particularly Th2, Biochem Biophys Res Commun 2011;407:764), thymus