Author: Nat Pernick, M.D.

Revised: 7 May 2018, last major update October 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CDC2[title]
Cite this page: Pernick, N. CDC2 / CDK1. website. Accessed October 20th, 2018.
Definition / general
  • Also called Cyclin Dependent Kinase 1
  • Member of cyclin dependent kinase family, which regulates phase transitions and checkpoints within the cell cycle
  • Nuclear protein that is subunit of M phase promoting factor, together with cyclin B subunit
  • Not expressed in normal esophagus; rare to occasional expression in Barrett’s esophagus with low grade dysplasia, increasing to diffuse expression in 95% with high grade dysplasia; expression correlates with progression of esophageal adenocarcinoma in cell lines (Am J Surg Pathol 2005;29:390)
  • EM-1521, a CDC2/CDK1 inhibitor, is theoretical antitumor therapy for esophageal adenocarcinoma
  • Low levels associated with reduced survival in mantle cell lymphoma (Mod Pathol 2005;18:1223)
  • Staining in mantle cell lymphoma is predominantly cytoplasmic and partial nuclear
Positive staining - normal
  • Germinal center (but not mantle zone) of benign lymph nodes