Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CDC2[title]
  • Also called Cyclin Dependent Kinase 1
  • Member of cyclin dependent kinase family, which regulates phase transitions and checkpoints within the cell cycle
  • Nuclear protein that is subunit of M phase promoting factor, together with cyclin B subunit
  • Not expressed in normal esophagus; rare to occasional expression in Barrett’s esophagus with low grade dysplasia, increasing to diffuse expression in 95% with high grade dysplasia; expression correlates with progression of esophageal adenocarcinoma in cell lines (Am J Surg Pathol 2005;29:390)
  • EM-1521, a CDC2/CDK1 inhibitor, is theoretical antitumor therapy for esophageal adenocarcinoma
  • Low levels associated with reduced survival in mantle cell lymphoma (Mod Pathol 2005;18:1223)
  • Staining in mantle cell lymphoma is predominantly cytoplasmic and partial nuclear
Positive Staining - Normal
  • Germinal center (but not mantle zone) of benign lymph nodes
Micro Images

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Staining in tonsil (fig 2b), mantle cell lymphoma (2e/2f)