CDC2 / CDK1

Stains
CDC2 / CDK1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 November 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CDC2[title]

Table of Contents

Definition / general | Interpretation | Positive staining - normal | Microscopic (histologic) images

Cite this page: CDC2 / CDK1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscdc2.html. Accessed July 12th, 2017.

Definition / general

Also called Cyclin Dependent Kinase 1
Member of cyclin dependent kinase family, which regulates phase transitions and checkpoints within the cell cycle
Nuclear protein that is subunit of M phase promoting factor, together with cyclin B subunit
Not expressed in normal esophagus; rare to occasional expression in Barrett’s esophagus with low grade dysplasia, increasing to diffuse expression in 95% with high grade dysplasia; expression correlates with progression of esophageal adenocarcinoma in cell lines (Am J Surg Pathol 2005;29:390)
EM-1521, a CDC2/CDK1 inhibitor, is theoretical antitumor therapy for esophageal adenocarcinoma
Low levels associated with reduced survival in mantle cell lymphoma (Mod Pathol 2005;18:1223)

Interpretation

Staining in mantle cell lymphoma is predominantly cytoplasmic and partial nuclear

Positive staining - normal

Germinal center (but not mantle zone) of benign lymph nodes

Microscopic (histologic) images

Images hosted on Nature.com:

Staining in tonsil (fig 2b), mantle cell lymphoma (2e/2f)