Topic Completed: 1 October 2013

Minor changes: 4 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: CDC2[title]

Nat Pernick, M.D.
Page views in 2019: 31
Page views in 2020 to date: 15
Cite this page: Pernick N. CDC2 / CDK1. website. Accessed May 27th, 2020.
Definition / general
  • Also called Cyclin Dependent Kinase 1
  • Member of cyclin dependent kinase family, which regulates phase transitions and checkpoints within the cell cycle
  • Nuclear protein that is subunit of M phase promoting factor, together with cyclin B subunit
  • Not expressed in normal esophagus; rare to occasional expression in Barrett’s esophagus with low grade dysplasia, increasing to diffuse expression in 95% with high grade dysplasia; expression correlates with progression of esophageal adenocarcinoma in cell lines (Am J Surg Pathol 2005;29:390)
  • EM-1521, a CDC2/CDK1 inhibitor, is theoretical antitumor therapy for esophageal adenocarcinoma
  • Low levels associated with reduced survival in mantle cell lymphoma (Mod Pathol 2005;18:1223)
  • Staining in mantle cell lymphoma is predominantly cytoplasmic and partial nuclear
Positive staining - normal
  • Germinal center (but not mantle zone) of benign lymph nodes
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