Stains & molecular markers
CDX2


Topic Completed: 1 December 2011

Minor changes: 2 September 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed Search: CDX2[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CDX2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscdx2.html. Accessed September 23rd, 2020.
Definition / general
  • Homeobox gene that encodes a nuclear transcription factor critical for intestinal embryonic development; relatively specific for intestinal epithelium (but see positive staining below)
Terminology
  • Also called caudal-related homeobox gene 2, caudal type homeobox transcription factor 2
  • Homologue of Drosophila melanogaster homeobox gene-caudal
Uses by pathologists
Microscopic (histologic) images

Contributed by GenomeMe

Colon (normal), clone IHC402



Images hosted on other servers:

Colonic medullary carcinoma

Quality control of CDX2 staining

Positive staining - normal
  • Nuclei of intestinal epithelium lining colonic villi and crypts, subset of epithelium of pancreas, stomach, esophagus
  • Urachal remants of glandular type, bladder intestinal metaplasia
Positive staining - disease
Negative staining
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