Stains
CDX2

Author: Nat Pernick, M.D.

Revised: 7 May 2018, last major update December 2011

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CDX2[title]
Cite this page: Pernick, N. CDX2. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscdx2.html. Accessed June 18th, 2018.
Definition / general
  • Homeobox gene that encodes a nuclear transcription factor critical for intestinal embryonic development; relatively specific for intestinal epithelium (but see positive staining below)
Terminology
  • Also called caudal-related homeobox gene 2, caudal type homeobox transcription factor 2
  • Homologue of Drosophila melanogaster homeobox gene-caudal
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Anal gland carcinoma is CDX2- (fig E)

Left-bladder adenocarcinoma is CDX2+ (fig C)

Left: primary colorectal carcinomas; middle: secondary colonic tumors; right: metastasis to brain (fig 2B)


Colonic medullary carcinoma

Missing Image

Stomach: poorly differentiated carcinoma

Tumors from various sites

Quality control of CDX2 staining

Carcinoid tumors: primary and metastatic


Positive staining - normal
  • Nuclei of intestinal epithelium lining colonic villi and crypts, subset of epithelium of pancreas, stomach, esophagus
  • Urachal remants of glandular type, bladder intestinal metaplasia
Positive staining - disease
Negative staining