Stains
CEA / CD66e


Topic Completed: 1 November 2014

Revised: 28 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CEA[title]

Related topics: General, CD66b, CD66c, CD66d, CD66f

Nat Pernick, M.D.
Page views in 2018: 11,669
Page views in 2019 to date: 7,066
Cite this page: Pernick N. CEA / CD66e. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscea.html. Accessed July 17th, 2019.
Definition / general
  • Also called CEA, carcinoembryonic antigen and CEACAM5
  • Either polyclonal (pCEA) or monoclonal (mCEA)
  • Normally detected in glycocalyx of fetal epithelial cells
  • May play a role in the metastasis of cancer cells
  • Usually considered an epithelial marker with strong staining in adenocarcinomas
Case reports
Uses by pathologists
Microscopic (histologic) images

Images hosted on Pathout server:
Courtesy of Andrey Bychkov, M.D., Ph.D.:

C cells in relation to thyroid follicle

Clustered C cells

Cervical adenoid cystic carcinoma



Images hosted on other servers:

Ampulla of Vater-Paneth cell carcinoma (figure G)

Breast adenoid cystic carcinoma (fig 13)

Positive signet ring cells (fig D)

Intestinal differentiation (fig D)

Colon inverted
hyperplastic polyp
(normal colon at
upper right is CEA-)


Gastric
adenocarcinoma
metastatic to
colon (fig 4)

Lung adenocarcinoma
metastatic to ovary
(figure 2B)

Medullary thyroid carcinoma (fig 7)

Paget disease of vulva (fig 11)

Paget disease of scrotum



Secretory meningioma (left, fig 10; right, fig 11)

   

Peritoneal benign multicystic
mesothelioma (an atypical
finding, fig 2F)

Sweat gland carcinoma(fig 8B)

Various images: quality control


Cytology images

Images hosted on other servers:

Cholangiocarcinoma (fig 8)

Positive staining - normal
  • Granulocytes and epithelial cells (apical surfaces)
  • Also biliary tract including gallbladder, colon (fetal), hepatocytes, prostatic secretory cells (25%) and small intestinal crypts
  • Small intestinal goblet cell mucin (not intracytoplasmic), thyroid cell nests and C cells
Positive staining - tumors
Negative staining
Back to top