Stains
CEA / CD66e

Author: Nat Pernick, M.D.

Revised: 7 May 2018, last major update November 2014

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CEA[title]

Related topics: General, CD66b, CD66c, CD66d, CD66f
Cite this page: Pernick, N. CEA / CD66e. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainscea.html. Accessed August 18th, 2018.
Definition / general
  • Also called CEA, carcinoembryonic antigen and CEACAM5
  • Either polyclonal (pCEA) or monoclonal (mCEA)
  • Normally detected in glycocalyx of fetal epithelial cells
  • May play a role in the metastasis of cancer cells
  • Usually considered an epithelial marker with strong staining in adenocarcinomas
Case reports
Uses by pathologists
Microscopic (histologic) images

Images hosted on Pathout server:
Courtesy of Andrey Bychkov, M.D., Ph.D.:

C cells in relation to thyroid follicle

Clustered C cells

Cervical adenoid cystic carcinoma



Images hosted on other servers:

Ampulla of Vater-Paneth cell carcinoma (figure G)

Breast adenoid cystic carcinoma (fig 13)

Positive signet ring cells (fig D)

Intestinal differentiation (fig D)

Colon inverted
hyperplastic polyp
(normal colon at
upper right is CEA-)


Gastric
adenocarcinoma
metastatic to
colon (fig 4)

Lung adenocarcinoma
metastatic to ovary
(figure 2B)

Medullary thyroid carcinoma (fig 7)

Paget disease of vulva (fig 11)

Paget disease of scrotum



Secretory meningioma (left, fig 10; right, fig 11)

   

Peritoneal benign multicystic
mesothelioma (an atypical
finding, fig 2F)

Sweat gland carcinoma(fig 8B)

Various images: quality control


Cytology images

Images hosted on other servers:

Cholangiocarcinoma (fig 8)

Positive staining - normal
  • Granulocytes and epithelial cells (apical surfaces)
  • Also biliary tract including gallbladder, colon (fetal), hepatocytes, prostatic secretory cells (25%) and small intestinal crypts
  • Small intestinal goblet cell mucin (not intracytoplasmic), thyroid cell nests and C cells
Positive staining - tumors
Negative staining