Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 November 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: chaperones[title]
Table of Contents
Definition / general
Cite this page: Chaperones. website. Accessed October 21st, 2018.
Definition / general
  • Proteins which help other proteins fold correctly by transient binding to interactive surfaces (hydrophobic areas), which otherwise might aggregate
  • Name is accurate since it has no actual positive effect but prevents negative effects
  • Important after environmental stress which causes proteins to unfold
  • As a translated protein grows, it becomes increasingly available to chaperones; the protein is released into the intracellular space only when it is folded enough to prevent aggregation