Stains
Chloroacetate esterase

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Chloroacetate esterase[title]
Table of Contents
Definition / General
Definition / General
  • Also called specific esterase, naphthol AS-D chloroacetate esterase
  • Useful for demonstrating myeloid differentiation, although negative in 25% of cases, particularly with immature granulocytic and monocytic neoplasms (Arch Pathol Lab Med 2005;129:32)
  • Enzyme cytochemistry-positive: AML-M1, M2, microgranular M3; granulocytic sarcomas, neutrophils
  • Enzyme cytochemistry-negative: ALL