Stains
Chloroacetate esterase


Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Chloroacetate esterase[title]

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Chloroacetate esterase. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainschloroacetate.html. Accessed September 23rd, 2019.
Definition / general
  • Also called specific esterase, naphthol AS-D chloroacetate esterase
  • Useful for demonstrating myeloid differentiation, although negative in 25% of cases, particularly with immature granulocytic and monocytic neoplasms (Arch Pathol Lab Med 2005;129:32)
  • Enzyme cytochemistry-positive: AML-M1, M2, microgranular M3; granulocytic sarcomas, neutrophils
  • Enzyme cytochemistry-negative: ALL
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