Stains
Cytokeratin 10 (CK10, K10)



Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CK10
Page views in 2018: 291
Page views in 2019 to date: 115
Cite this page: Pernick N. Cytokeratin 10 (CK10, K10). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsck10.html. Accessed May 24th, 2019.
Definition / general
  • Molecular weight of 56.5 kDa
  • Partner of CK1
  • CK1 and CK10 are present in suprabasal terminally differentiating cells
  • Mutations in CK10 or CK1 cause epidermolytic hyperkeratosis / bullous congenital ichthyosiform erythroderma of Brocq (Hum Mol Genet 2006;15:1133, Dermatol Online J 2006;12:6); defects of CK10-CK1 protein network cause structural instability and weakness of keratinocytes, causing blistering, hyperproliferation and hyperkeratosis
  • CK10 is putative autoantigen in chronic, antibiotic resistant Lyme arthritis (J Immunol 2006;177:2486)
Uses by pathologists
Positive staining - normal
  • Epidermal spinous and granular cell layers
Positive staining - disease
Additional references
Back to top