Cytokeratin 10 (CK10, K10)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 9 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CK10
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Cite this page: Cytokeratin 10 (CK10, K10). website. Accessed January 22nd, 2019.
Definition / general
  • Molecular weight of 56.5 kDa
  • Partner of CK1
  • CK1 and CK10 are present in suprabasal terminally differentiating cells
  • Mutations in CK10 or CK1 cause epidermolytic hyperkeratosis / bullous congenital ichthyosiform erythroderma of Brocq (Hum Mol Genet 2006;15:1133, Dermatol Online J 2006;12:6); defects of CK10-CK1 protein network cause structural instability and weakness of keratinocytes, causing blistering, hyperproliferation and hyperkeratosis
  • CK10 is putative autoantigen in chronic, antibiotic resistant Lyme arthritis (J Immunol 2006;177:2486)
Uses by pathologists
Positive staining - normal
  • Epidermal spinous and granular cell layers
Positive staining - disease
Additional references