Cytokeratin 12 (CK12, K12)

Stains
Cytokeratin 12 (CK12, K12)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CK12

Table of Contents

Definition / general | Uses by pathologists | Positive staining - normal | Additional references

Cite this page: Cytokeratin 12 (CK12, K12). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsck12.html. Accessed July 12th, 2017.

Definition / general

Molecular weight is 53.5 kDa
Pairs with CK3
Maintains corneal epithelial integrity (Invest Ophthalmol Vis Sci 1996;37:2572)
Mutations cause Meesmann corneal dystrophy (Am J Hum Genet 1997;61:1268)

Uses by pathologists

No significant clinical use by pathologists

Positive staining - normal

Conjunctival limbic suprabasal epithelial cells and corneal basal and suprabasal layers (Invest Ophthalmol Vis Sci 2006;47:1359)

Additional references

OMIM 601687