Cytokeratin 13 (CK13, K13)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CK13[title]
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Cite this page: Cytokeratin 13 (CK13, K13). website. Accessed February 19th, 2019.
Definition / general
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Suprabasal layers of non-cornified stratified epithelium, including squamous (non-keratinized) epithelia of cervix, esophagus, larynx, oral cavity, tonsils, urothelium, and respiratory-type epithelium
  • May be filled with mucoid material or foamy macrophages
Positive staining - disease
  • Brenner tumor
  • Squamous metaplasia
  • Squamous cell carcinoma (10%)
  • Urothelial carcinoma (well differentiated)
Negative staining
  • Epidermis
Additional references