Stains
Cytokeratin 2 (CK2, K2)



Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: ck2[title]
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Cite this page: Pernick N. Cytokeratin 2 (CK2, K2). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsck2.html. Accessed May 24th, 2019.
Definition / general
  • Molecular weight (CK2e) is 65.5-65.8 kDa
  • Associates with CK10
  • Mutations cause ichthyosis bullosa of Siemens (Br J Dermatol 2005;152:1353)
  • K2e (epidermis) and K2p (palate) are encoded by separate genes, with < 75% identity at primary structural level; thus, are not true isoforms, although they cannot be distinguished by conventional 2D electrophoresis
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Additional references
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