Cytokeratin 2 (CK2, K2)
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 16 October 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: CK2[title]
- Molecular weight (CK2e) is 65.5-65.8 kDa
- Associates with CK10
- Mutations cause ichthyosis bullosa of Siemens (Br J Dermatol 2005;152:1353)
- K2e (epidermis) and K2p (palate) are encoded by separate genes, with < 75% identity at primary structural level; thus, are not true isoforms, although they cannot be distinguished by conventional 2D electrophoresis
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
End of Stains > Cytokeratin 2 (CK2, K2)
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