Cytokeratin 2 (CK2, K2)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: ck2[title]
Cite this page: Cytokeratin 2 (CK2, K2). website. Accessed March 22nd, 2018.
Definition / general
  • Molecular weight (CK2e) is 65.5-65.8 kDa
  • Associates with CK10
  • Mutations cause ichthyosis bullosa of Siemens (Br J Dermatol 2005;152:1353)
  • K2e (epidermis) and K2p (palate) are encoded by separate genes, with < 75% identity at primary structural level; thus, are not true isoforms, although they cannot be distinguished by conventional 2D electrophoresis
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Additional references