Cytokeratin 3 (CK3, K3)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: ck3
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Cite this page: Cytokeratin 3 (CK3, K3). website. Accessed January 18th, 2019.
Definition / general
  • Molecular weight is 64-65 kDa
  • Associates with CK12
  • Mutations in KRT3 gene may cause Meesmann corneal dystrophy (Cornea 2005;24:928)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Corneal epithelium (full thickness), limbus epithelium (suprabasal)
Negative staining
  • Conjunctival epithelium
Microscopic (histologic) images

Suprabasal staining of limbus epithelium cultured using air-lifting (AL) technique (fig A/B)

Additional references