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Stains
Cytokeratin 34 beta E12

Reviewer: Kara Hamilton, M.S., Nat Pernick, M.D. (see Reviewers page)
Revised: 13 July 2013, last major update June 2009
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Uses by pathologists
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Micro images
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Kidney: collecting duct carcinoma with signet ring features

Skin: squamous cell carcinoma-acantholytic type

Thyroid anaplastic carcinoma


Prostate:

Normal

Atrophy with pseudoinfiltrative growth pattern

Basal cell hyperplasia

Post-atrophic hyperplasia

Sclerosing adenosis


Atypical adenomatous hyperplasia

Staining without and with antigen retrieval


High grade PIN: #1-tufting pattern with 34BE12 staining; #2-micropapillary pattern; #3-flat pattern; #4-with foamy cytoplasm; #5-with adenocarcinoma


Prostatic adenocarcinoma is negative with occasional positive benign glands


Adenoid basal cell tumor

Urothelial type adenocarcinoma with
mucin production is focally 34BE12+

Low-grade bladder neoplasms


Positive staining - normal
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Positive staining - not carcinoma
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Positive staining - carcinoma
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Negative staining
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End of Stains > Cytokeratin 34 beta E12


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