Cytokeratin 34 beta E12

Author: Kara Hamilton, MS, Nat Pernick, M.D.

Revised: 24 May 2018, last major update July 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: 34betaE12[title]
Cite this page: Hamilton, K., Pernick, N. Cytokeratin 34 beta E12. website. Accessed October 21st, 2018.
Definition / general
  • High molecular weight keratin relatively specific for prostate basal cells
  • Reacts to CK1, CK5, CK10 and CK14 and possibly other keratins
  • Also called CK903, high molecular weight keratin
Uses by pathologists
Microscopic (histologic) images

Images hosted on Pathout server:

Contributed by Dr. Stephen J. Schultenover, Vanderbilt University, Tennessee

Thyroid anaplastic carcinoma

Images hosted on other servers:

Prostate: normal

Prostate: basal cell hyperplasia

Prostate: postatrophic hyperplasia

Atypical adenomatous hyperplasia

Staining without and with antigen retrieval

High grade PIN: with adenocarcinoma

Prostatic adenocarcinoma is negative with occasional positive benign glands

Adenoid basal cell tumor

Low grade bladder neoplasms

Positive staining - normal
Positive staining - not malignant
Positive staining - malignant
Negative staining