Cytokeratin 4 (CK4, K4)

Stains
Cytokeratin 4 (CK4, K4)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: ck4[title]

Table of Contents

Cite this page: Cytokeratin 4 (CK4, K4). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsck4.html. Accessed July 12th, 2017.

Definition / general

Molecular weight is 59 kDa
Associates with CK13
Downregulated in head and neck squamous cell carcinoma (Acta Otolaryngol 2006;126:967)

Uses by pathologists

No significant clinical use by pathologists

Case reports

Young man with novel mutation in the keratin 4 gene causing white sponge naevus (Br J Dermatol 2003;148:1125)

Positive staining - normal

Suprabasal cells of nonkeratinized stratified squamous epithelium of esophagus and cornea; also anus, larynx, pharynx, tongue (J Biol Chem 1998;273:23912)

Microscopic (histologic) images

Images hosted on Nature.com:

Epidermis before and after treatment with retinoic acid

Additional references

OMIM 123940