Cytokeratin 6 (CK6, K6)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: ck6
Cite this page: Cytokeratin 6 (CK6, K6). website. Accessed February 25th, 2018.
Definition / general
Uses by pathologists
Positive staining - normal
  • Esophagus, epidermal and epithelial glands, hair and nails, oral mucosa, stomach, tongue (filiform papillae)
Positive staining - disease
  • Psoriasis, other skin disorders (see above)
Microscopic (histologic) images

Images hosted on other servers:

Breast carcinoma-basal subtype in BRCA1 patient

Gallbladder adenosquamous carcinoma

Keratoconus (fig A), normal cornea (fig D)

Mesothelioma-deciduoid (fig 5)

Squamous cell carcinoma-oral (fig a)

Benign epithelial inclusions of axillary lymph nodes - fig 1: CK5/6+; 2: p63+

Images hosted on

Ovarian serous carcinoma (fig b)

Pancreas-adenosquamous carcinoma

Skin-various images

Various images #1 (squamous cell-fig 1A, urothelial-fig 1C, thymoma-fig 1E, salivary gland adenoid cystic-fig 1G)

#2 (ovary-fig 2A, endometrioid adenocarcinoma of uterus-fig 2C, infiltrating ductal carcinoma of breast-fig 2E)