Stains
Cytokeratin 6 (CK6, K6)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: ck6
Cite this page: Cytokeratin 6 (CK6, K6). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsck6.html. Accessed December 6th, 2016.
Definition / General
Uses by Pathologists
Positive Staining - Normal
  • Esophagus, epidermal and epithelial glands, hair and nails, oral mucosa, stomach, tongue (filiform papillae)
Positive Staining - Disease
  • Psoriasis, other skin disorders (see above)
Micro Images

Images hosted on other servers:

Breast carcinoma-basal subtype in BRCA1 patient

Gallbladder adenosquamous carcinoma

Keratoconus (fig A), normal cornea (fig D)

Mesothelioma-deciduoid (fig 5)

Squamous cell carcinoma-oral (fig a)


Benign epithelial inclusions of axillary lymph nodes - fig 1: CK5/6+; 2: p63+



Images hosted on Nature.com:

Ovarian serous carcinoma (fig b)

Pancreas-adenosquamous carcinoma


Skin-various images


Various images #1 (squamous cell-fig 1A, urothelial-fig 1C, thymoma-fig 1E, salivary gland adenoid cystic-fig 1G)


#2 (ovary-fig 2A, endometrioid adenocarcinoma of uterus-fig 2C, infiltrating ductal carcinoma of breast-fig 2E)