Cytokeratin 8 (CK8, K8)

Author: Nat Pernick, M.D.

Revised: 23 May 2018, last major update October 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CK8[title]
Cite this page: Pernick, N. Cytokeratin 8 (CK8, K8). website. Accessed October 20th, 2018.
Definition / general
Uses by pathologists
Positive staining - normal
  • Gallbladder
  • Intestine
  • Liver (hepatocytes and bile ductules)
  • Pancreas
  • Prostate (basal cells and secretory cells)
  • Simple type (single layer) epithelium including breast ducts (luminal cells)
Positive staining - not malignant
Positive staining - malignant
Negative staining
Microscopic (histologic) images

Contributed by Leica Microsystems (Biosystems Division)

Colon (normal)
CK8 / 18 (5D3)
with intense cytoplasmic
and membranous staining

Images hosted on other servers:

Hepatic blastoma-adult (fig D)

Hepatocytes (residual)
are CK8+ in embryonal
sarcoma of liver

Liver disease (various)

Prostatic adenocarcinoma-top and benign prostate bottom

Squamous cell carcinoma-oral (fig C/D)

Additional references