Stains
Cytokeratin 8 (CK8, K8)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 December 2015, last major update October 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CK8[title]
Definition / General
Uses by Pathologists
Positive Staining - Normal
  • Gallbladder
  • Intestine
  • Liver (hepatocytes and bile ductules)
  • Pancreas
  • Prostate (basal cells and secretory cells)
  • Simple type (single layer) epithelium including breast ducts (luminal cells)
Positive Staining - Not Malignant
Positive Staining - Malignant
Negative Staining
Micro Images

Images hosted on Pathout server:

Contributed by Leica Microsystems, Biosystems Division-

Colon (normal)-Cytokeratin 8/18 (5D3) with
intense cytoplasmic and membranous staining



Images hosted on other servers:

Hepatic blastoma-adult (fig D)

Hepatocytes (residual) are CK8+ in embryonal sarcoma of liver

Liver disease (various)

Prostatic adenocarcinoma-top and benign prostate-bottom


Squamous cell carcinoma-oral (fig C/D)



Images hosted on Nature.com:

Malignant rhabdoid tumor (fig C)

Additional References