Cytokeratin 8 (CK8, K8)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 December 2015, last major update October 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: CK8[title]
Cite this page: Cytokeratin 8 (CK8, K8). website. Accessed May 21st, 2018.
Definition / general
Uses by pathologists
Positive staining - normal
  • Gallbladder
  • Intestine
  • Liver (hepatocytes and bile ductules)
  • Pancreas
  • Prostate (basal cells and secretory cells)
  • Simple type (single layer) epithelium including breast ducts (luminal cells)
Positive staining - not malignant
Positive staining - malignant
Negative staining
Microscopic (histologic) images

Images hosted on Pathout server:

Contributed by Leica Microsystems, Biosystems Division-

Colon (normal)-Cytokeratin 8/18 (5D3) with
intense cytoplasmic and membranous staining

Images hosted on other servers:

Hepatic blastoma-adult (fig D)

Hepatocytes (residual) are CK8+ in embryonal sarcoma of liver

Liver disease (various)

Prostatic adenocarcinoma-top and benign prostate-bottom

Squamous cell carcinoma-oral (fig C/D)

Images hosted on

Malignant rhabdoid tumor (fig C)

Additional references