Stains
Cytokeratin 8 (CK8, K8)



Topic Completed: 1 October 2013

Revised: 4 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: CK8[title]
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Cite this page: Pernick N. Cytokeratin 8 (CK8, K8). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsck8.html. Accessed March 24th, 2019.
Definition / general
Uses by pathologists
Positive staining - normal
  • Gallbladder
  • Intestine
  • Liver (hepatocytes and bile ductules)
  • Pancreas
  • Prostate (basal cells and secretory cells)
  • Simple type (single layer) epithelium including breast ducts (luminal cells)
Positive staining - not malignant
Positive staining - malignant
Negative staining
Microscopic (histologic) images

Contributed by Leica Microsystems (Biosystems Division)

Colon (normal)
CK8 / 18 (5D3)
with intense cytoplasmic
and membranous staining



Images hosted on other servers:

Hepatic blastoma-adult (fig D)

Hepatocytes (residual)
are CK8+ in embryonal
sarcoma of liver

Liver disease (various)

Prostatic adenocarcinoma-top and benign prostate bottom

Squamous cell carcinoma-oral (fig C/D)

Additional references
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