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Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Claudin1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclaudin1.html. Accessed July 12th, 2017.
Definition / general
- Tight junction-associated protein first identified in 1998 (J Cell Biol 1998;141:1539)
- Also called CLDN1, Senescence-associated Epithelial Membrane Protein 1 (SEMP1)
- Has role in cell entry of Hepatitis C virus (Nature 2007;446:801) and Dengue virus (Biochem Biophys Res Commun 2010;391:952)
- Defects cause ichthyosis-sclerosing cholangitis neonatal syndrome (OMIM #607626)
- Interpretation: particulate staining along cell membrane (Am J Surg Pathol 2002;26:1620)
- References: OMIM #603718
Uses by pathologists
- Diagnosis of meningioma (with EMA) and to distinguish from hemangiopericytoma (Hum Pathol 2004;35:1413, Am J Clin Pathol 2006;125:203)
- Marker for perineurium (Am J Surg Pathol 2008;32:1088) / diagnosis of perineurioma (Arch Pathol Lab Med 2007;131:625), but does not distinguish from low grade fibromyxoid sarcoma
- Sensitive marker for ovarian adenocarcinoma in effusions (Am J Clin Pathol 2007;127:928)
- Low levels associated with poor survival in stage II colon carcinoma (Mod Pathol 2005;18:511), recurrence in prostatic adenocarcinoma (Hum Pathol 2007;38:564)
- Marker for epithelial differentiation (Mod Pathol 2005;18:1403, Mod Pathol 2004;17:141)
Microscopic (histologic) images
Images hosted on other servers:
Meningioma (fig 3B)
Images hosted on Nature.com:
Renal tissue (non-neoplastic, fig 1A)
Renal tumors - various
Biphasic synovial sarcoma (left, fig B; right, fig C)
Colon tumors (fig A)
Monophasic synovial sarcoma (fig C)
Poorly differentiated synovial sarcoma (fig c)
Typical ES/PNET (fig C)
Adamantinoma-like ES/PNET (fig c)
Lung squamous cell carcinomas vs. adenocarcinomas (fig A-D)
Positive staining - normal
- Brain, heart, kidney (strong), liver (strong), lung, spleen and testis
- Also normal perineurium and endothelial cells
Positive staining - disease
- Gastric adenocarcinoma (intestinal-74%, diffuse-46%, Hum Pathol 2005;36:886)
- Hepatoblastoma, fetal component (Hum Pathol 2006;37:555)
- Low grade fibromyxoid sarcoma (100%, Hum Pathol 2009;40:1586)
- Meningioma (53%, Am J Clin Pathol 2006;125:203)
- Perineuriomas - intestinal (40-93%, Am J Surg Pathol 2005;29:859, Am J Surg Pathol 2008;32:1088), soft tissue (29%, Am J Surg Pathol 2005;29:845)
- Pulmonary squamous cell carcinoma (Mod Pathol 2007;20:947)
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