Stains - Claudin-1

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Stains

Claudin-1

Authors: Nat Pernick, M.D., PathologyOutlines.com, Inc.

Revised: 22 September 2012, last major update - April 2010

Definition

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● Tight junction-associated protein first identified in 1998 (J Cell Biol 1998;141:1539)

Terminology

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● Also called CLDN1, Senescence-associated Epithelial Membrane Protein 1 (SEMP1)

Mechanism

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● Has role in cell entry of Hepatitis C virus (Nature 2007;446:801) and Dengue virus (Biochem Biophys Res Commun 2010;391:952)

● Defects cause ichthyosis-sclerosing cholangitis neonatal syndrome (OMIM:607626)

Uses

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● Diagnosis of meningioma (with EMA) and to distinguish from hemangiopericytoma (Hum Pathol 2004;35:1413, Am J Clin Pathol 2006;125:203)

● Marker for perineurium (Am J Surg Pathol 2008;32:1088) / diagnosis of perineurioma (Arch Pathol Lab Med 2007;131:625, but does not distinguish from low grade fibromyxoid sarcoma)

● Sensitive marker for ovarian adenocarcinoma in effusions (Am J Clin Pathol 2007;127:928)

● Low levels associated with poor survival in stage II colon carcinoma (Mod Pathol 2005;18:511), recurrence in prostatic adenocarcinoma (Hum Pathol 2007;38:564)

● Marker for epithelial differentiation (Mod Pathol 2005;18:1403, Mod Pathol 2004;17:141)

Interpretation

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● Particulate staining along cell membrane (Am J Surg Pathol 2002;26:1620)

Positive stains - normal

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● Brain, heart, kidney (strong), liver (strong), lung, spleen, testis

● Also normal perineurium and endothelial cells

Positive stains - disease

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● Gastric adenocarcinoma (intestinal-74%, diffuse-46%, Hum Path 2005;36:886)

● Hepatoblastoma, fetal component (Hum Pathol 2006;37:555)

● Low grade fibromyxoid sarcoma (100%, Hum Pathol 2009;40:1586)

● Meningioma (53%, Am J Clin Pathol 2006;125:203)

● Perineuriomas - intestinal (40-93%, Am J Surg Pathol 2005;29:859, Am J Surg Pathol 2008;32:1088), soft tissue (29%, Am J Surg Pathol 2005;29:845)

● Pulmonary squamous cell carcinoma (Mod Pathol 2007;20:947)

Micro images

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Renal tissue (nonneoplastic)

Fig 1a

Meningioma: Fig 3B Renal tumors-various

Additional references

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References: OMIM 603718

End of Stains > Claudin-1

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