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Table of Contents
Definition / general | Terminology | Clinical features | Interpretation | Microscopic (histologic) images | Positive staining - disease | Negative stainingCite this page: Claudin18. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclaudin18.html. Accessed July 12th, 2017.
Definition / general
- Claudins are large family of tight junction proteins with 4 transmembrane domains
- Claudins function to produce a seal between cells, with critical role in maintaining cell polarity
- Claudin18, first described in 2001 (Mol Cell Biol 2001;21:7380) is highly conserved member, specific for gastric and lung tissue (Gene 2011;481:83)
Terminology
- Also called CLDN18
Clinical features
- Expression may contribute to greater acid resistance of Barrett's esophagus (Am J Physiol Gastrointest Liver Physiol 2007;293:G1106)
Interpretation
- Membranous staining
Microscopic (histologic) images
Images hosted on other servers:
Normal lung and stomach (Claudin18 Splice Variant 2)
Pancreas: PanIN (left), infiltrating ductal carcinoma (right)
Carcinomas of stomach, esophagus, ovary (Claudin18 Splice Variant 2)
Positive staining - disease
- Bile duct: biliary intraepithelial neoplasia (78%), extrahepatic bile duct carcinoma (90%), intrahepatic (100%) and extrahepatic (89%) intraductal papillary neoplasm of bile duct (100%), intrahepatic cholangiocarcinoma (43%, Virchows Arch 2011;459:73)
- Pancreas: PanIN, intraductal papillary mucinous neoplasms, mucinous cystic neoplasms, infiltrating ductal adenocarcinoma (Am J Surg Pathol 2008;32:188, J Histochem Cytochem 2011;59:942)
- Signet ring adenocarcinoma (gastric 86%, colorectal 38%, not breast or lung, Am J Surg Pathol 2008;32:1182)
- Urachal adenocarcinoma (Am J Surg Pathol 2011;35:787)
Negative staining
- Non-neoplastic pancreas
- Urachal remnants and benign disorders (Am J Surg Pathol 2011;35:787)
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