Author: Nat Pernick, M.D.

Revised: 10 August 2018, last major update December 2011

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CLDN18
Page views in 2018: 34
Page views in 2019 to date: 4
Cite this page: Pernick, N. Claudin18. website. Accessed January 17th, 2019.
Definition / general
  • Claudins are large family of tight junction proteins with 4 transmembrane domains
  • Claudins function to produce a seal between cells, with critical role in maintaining cell polarity
  • Claudin18, first described in 2001 (Mol Cell Biol 2001;21:7380) is highly conserved member, specific for gastric and lung tissue (Gene 2011;481:83)
  • Also called CLDN18
Clinical features
  • Membranous staining
Microscopic (histologic) images

Images hosted on other servers:

Normal lung and stomach (Claudin18 splice variant 2)

Pancreas: PanIN (left), infiltrating ductal carcinoma (right)

Carcinomas of
stomach, esophagus,
ovary (Claudin18 splice
variant 2)

Positive staining - disease
Negative staining