Stains
Claudin18

Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 December 2015, last major update December 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CLDN18
Definition / General
  • Claudins are large family of tight junction proteins with 4 transmembrane domains
  • Claudins function to produce a seal between cells, with critical role in maintaining cell polarity
  • Claudin18, first described in 2001 (Mol Cell Biol 2001;21:7380) is highly conserved member, specific for gastric and lung tissue (Gene 2011;481:83)
Terminology
  • Also called CLDN18
Clinical Features
Interpretation
  • Membranous staining
Micro Images

Images hosted on other servers:

Normal lung and stomach (Claudin18 Splice Variant 2)


Pancreas: PanIN (left), infiltrating ductal carcinoma (right)


Carcinomas of stomach, esophagus, ovary (Claudin18 Splice Variant 2)

Positive Staining - Disease
Negative Staining