Advertisement
Advertisement
Table of Contents
Definition / general | Clinical features | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Claudin5. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclaudin5.html. Accessed July 12th, 2017.
Definition / general
- Endothelial tight junction protein, encoded by CLDN5 gene (Wikipedia), present in dermal capillaries and other vessels (but not postcapillary venules); also in umbilical and coronary arteries (but not veins), some epithelium (Arterioscler Thromb Vasc Biol 2013;33:489)
- Regulated by ubiquitin-proteasome pathway (J Cell Biochem 2012;113:2415)
Clinical features
- Poor prognostic factor in breast (J Exp Clin Cancer Res 2012;31:43) and pancreatic adenocarcinoma (Tumour Biol 2014;35:3803)
- Downregulation causes various vascular leakage syndromes:
- Anthrax related pleural effusion and hemorrhage may be due to claudin5 downregulation by anthrax lethal toxin (PLoS One 2013;8:e62576)
- Edema in nasal polyps may be due to decreased claudin5 expression in vascular endothelium (Cell Tissue Res 2013;352:647)
- Ascities in ovarian cancer may be due to claudin5 downregulation by VEGF (Gynecol Oncol 2012;127:210)
- Blood brain barrier disrupted by HIV1 via changes in claudin5 expression (Methods Mol Biol 2011;762:355)
Uses by pathologists
- Strong membranous expression of claudin5 and claudin7 differentiates pancreatic solid pseudopapillary tumor from pancreatoblastoma, acinar cell and endocrine tumors (Am J Surg Pathol 2009;33:768, Zhonghua Bing Li Xue Za Zhi 2013;42:372)
Microscopic (histologic) images
Images hosted on other servers:
Breast: normal and malignant
Ovary: serous papillary adenocarcinoma
Positive staining - normal
- CNS: tight junctions of endothelial cells forming blood-brain barrier (World J Gastroenterol 2012;18:2132, J Cereb Blood Flow Metab 2012;32:860)
- Endothelial cells (tight junctions) and some epithelial cells
- Pancreas: acinar, endothelial, ductal tight junctions (World J Gastroenterol 2012;18:2132, Dev Dyn 2012;241:583)
Positive staining - disease
- Angiosarcoma and hemangioendothelioma; biphasic synovial sarcoma (Am J Surg Pathol 2011;35:1848)
- Pancreatic solid pseudopapillary tumor: intense membranous claudin 5 expression (Am J Surg Pathol 2009;33:768)
- Many carcinomas (weaker expression than in angiosarcoma)
Advertisement
