Pathology Outlines

Stains
Claudin 6

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 December 2015, last major update June 2012

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: claudin-6

Table of Contents

Cite this page: Claudin 6. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsclaudin6.html. Accessed July 12th, 2017.

Definition / general

Also called CLDN6
Tight junction protein mostly restricted to embryonic and fetal life (BMC Cancer 2006 Jul 12;6:186)
Membranous staining
May act as tumor suppressor in breast cancer cell lines (Eur J Cancer Prev 2010;19:186)
Coreceptor for Hepatitis C virus (J Virol 2007;81:12465)

Uses by pathologists

No definite uses at this time

Microscopic (histologic) images

Images hosted on other servers:

Breast: normal (left) and invasive ductal carcinoma (right)

Breast: variable staining in invasive ductal carcinoma

Stomach: normal (left) and gastric adenocarcinoma (right)

Positive staining - normal

Tight junction protein mostly restricted to embryonic and fetal life

Positive staining - disease

Breast invasive ductal carcinoma (variable, J Breast Cancer 2011;14:20)
Stains many atypical teratoid or rhabdoid tumors (Am J Surg Pathol 2010;34:341), but also expressed in other pediatric CNS and soft tissue tumors (Am J Surg Pathol 2012;36:73)

Negative staining

Downregulated in breast invasive ductal carcinoma (Diagn Pathol 2012;7:33)