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Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Also called CLDN6
● Tight junction protein mostly restricted to embryonic and fetal life (BMC Cancer 2006 Jul 12;6:186)
● Membranous staining
● May act as tumor suppressor in breast cancer cell lines (Eur J Cancer Prev 2010;19:186)
● Coreceptor for Hepatitis C virus (J Virol 2007;81:12465)

Uses by pathologists

● No definite uses at this time

Micro images

Breast: normal (left) and invasive ductal carcinoma (right)

Breast: variable staining in invasive ductal carcinoma

Stomach: normal (left) and gastric adenocarcinoma (right)

Positive staining - normal

● Tight junction protein mostly restricted to embryonic and fetal life

Positive staining - disease

● Breast invasive ductal carcinoma (variable, J Breast Cancer 2011;14:20)
● Stains many atypical teratoid or rhabdoid tumors (Am J Surg Pathol 2010;34:341), but also expressed in other pediatric CNS and soft tissue tumors (Am J Surg Pathol 2012;36:73)

Negative staining

● Downregulated in breast invasive ductal carcinoma (Diagn Pathol 2012;7:33)

End of Stains > Claudin-6

Ref Updated: 6/7/12

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