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Stains

Claudin-6


Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 11 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.

Definition
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● Also called CLDN6
● Tight junction protein mostly restricted to embryonic and fetal life (BMC Cancer 2006 Jul 12;6:186)
● Membranous staining
● May act as tumor suppressor in breast cancer cell lines (Eur J Cancer Prev 2010;19:186)
● Coreceptor for Hepatitis C virus (J Virol 2007;81:12465)

Uses by pathologists
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● No definite uses at this time

Micro images
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Breast: normal (left) and invasive ductal carcinoma (right)


Breast: variable staining in invasive ductal carcinoma


Stomach: normal (left) and gastric adenocarcinoma (right)

Positive staining - normal
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● Tight junction protein mostly restricted to embryonic and fetal life

Positive staining - disease
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● Breast invasive ductal carcinoma (variable, J Breast Cancer 2011;14:20)
● Stains many atypical teratoid or rhabdoid tumors (Am J Surg Pathol 2010;34:341), but also expressed in other pediatric CNS and soft tissue tumors (Am J Surg Pathol 2012;36:73)

Negative staining
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● Downregulated in breast invasive ductal carcinoma (Diagn Pathol 2012;7:33)

End of Stains > Claudin-6

Ref Updated: 6/7/12


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