Stains - Claudin-7

Home Chapter Home Jobs Conferences Fellowships Books

Stains

Claudin-7

Authors: Nat Pernick, M.D., PathologyOutlines.com, Inc.

Revised: 22 September 2012, last major update - April 2010

Definition

=========================================================================

● Has full length form (211 amino acids) and C-terminal truncated form (158 amino acids)

Terminology

=========================================================================

● Also known as CLDN7

Uses

=========================================================================

● High expression may be poor prognostic factor in: nasopharyngeal carcinoma (Hum Pathol 2010 Mar 22 [Epub ahead of print]), ovarian carcinoma (expression in serous effusions, Hum Pathol 2008;39:747)

● Membranous claudin-7 and negative claudin-8 may differentiate chromophobe renal cell carcinoma from onococytoma (Hum Pathol 2009;40:206)

Clinical

=========================================================================

● Important in aspirin-induced gastric barrier loss (Am J Physiol Cell Physiol 2008;295:C800)

Interpretation

=========================================================================

● Membranous expression

Positive stains - normal

=========================================================================

● Kidney (distal nephron epithelium), lung, prostate (J Membr Biol 2003;194:187)

Positive stains - disease

=========================================================================

● Ovarian adenocarcinoma (Am J Clin Pathol 2007;127:928, Int J Gynecol Cancer 2008;18:1262)

● Pancreatic solid pseudopapillary tumor (Am J Surg Pathol 2009;33:768)

● Renal cell carcinoma, chromophobe type (67%, Arch Pathol Lab Med 2007;131:1541)

● Synovial sarcoma, biphasic (J Biol Chem 2006;281:38941

Negative stains

=========================================================================

●

Micro images

=========================================================================

Renal tissue (nonneoplastic)

Fig 1d

Renal tumors Synovial sarcoma

Additional references

=========================================================================

References: NCBI Entrez Gene

End of Stains > Claudin-7

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by Copyright, (c) 2001-2010, PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions.